Vesicular glutamate transporter 3

Vesicular glutamate transporter 3 (VGLUT3) is a protein that in humans is encoded by the SLC17A8 gene.[5]

SLC17A8
Identifiers
AliasesSLC17A8, DFNA25, VGLUT3, solute carrier family 17 member 8
External IDsOMIM: 607557 MGI: 3039629 HomoloGene: 13584 GeneCards: SLC17A8
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q23.1Start100,357,074 bp[1]
End100,422,055 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

246213

216227

Ensembl

ENSG00000179520

ENSMUSG00000019935

UniProt

Q8NDX2

Q8BFU8

RefSeq (mRNA)

NM_139319
NM_001145288

NM_182959
NM_001310710

RefSeq (protein)

NP_001138760
NP_647480

NP_001297639
NP_892004

Location (UCSC)Chr 12: 100.36 – 100.42 MbChr 10: 89.57 – 89.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft.[5]

Clinical significance

Mutations in this gene are the cause of autosomal-dominant nonsyndromic deafness type 25 (DFNA25).[6][7]

gollark: But which runs much faster.
gollark: ```pythonfrom requests_futures.sessions import FuturesSessionimport concurrent.futures as futuresimport randomtry: import cPickle as pickleexcept ImportError: import pickletry: words_to_synonyms = pickle.load(open(".wtscache")) synonyms_to_words = pickle.load(open(".stwcache"))except: words_to_synonyms = {} synonyms_to_words = {}def add_to_key(d, k, v): d[k] = d.get(k, set()).union(set(v))def add_synonyms(syns, word): for syn in syns: add_to_key(synonyms_to_words, syn, [word]) add_to_key(words_to_synonyms, word, syns)def concat(list_of_lists): return sum(list_of_lists, [])def add_words(words): s = FuturesSession(max_workers=100) future_to_word = {s.get("https://api.datamuse.com/words", params={"ml": word}): word for word in words} future_to_word.update({s.get("https://api.datamuse.com/words", params={"ml": word, "v": "enwiki"}): word for word in words}) for future in futures.as_completed(future_to_word): word = future_to_word[future] try: data = future.result().json() except Exception as exc: print(f"{exc} fetching {word}") else: add_synonyms([w["word"] for w in data], word)def getattr_hook(obj, key): results = list(synonyms_to_words.get(key, set()).union(words_to_synonyms.get(key, set()))) if len(results) > 0: return obj.__getattribute__(random.choice(results)) else: raise AttributeError(f"Attribute {key} not found.")def wrap(obj): add_words(dir(obj)) obj.__getattr__ = lambda key: getattr_hook(obj, key)wrap(__builtins__)print(words_to_synonyms["Exception"])```New version which tends to reduce weirder output.
gollark: https://github.com/joelgrus/fizz-buzz-tensorflow/blob/master/Fizz%20Buzz%20in%20Tensorflow.ipynb
gollark: ?remind 5d Misuse ?remind even more. Suggestions: nested reminds (is that possible)?
gollark: Wow, 5 days ago? Cool!

References
  1. GRCh38: Ensembl release 89: ENSG00000179520 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019935 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter)".
  6. Online Mendelian Inheritance in Man (OMIM): 605583
  7. Ruel J, Emery S, Nouvian R, et al. (August 2008). "Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice". Am. J. Hum. Genet. 83 (2): 278–92. doi:10.1016/j.ajhg.2008.07.008. PMC 2495073. PMID 18674745.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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