Cationic amino acid transporter 3

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.[5][6]

SLC7A3
Identifiers
Aliases	SLC7A3, ATRC3, CAT-3, CAT3, solute carrier family 7 member 3
External IDs	OMIM: 300443 MGI: 1100521 HomoloGene: 56382 GeneCards: SLC7A3
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 70,925,579 bp[1] End 70,931,125 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 101,079,210 bp[2] End 101,086,020 bp[2]
Gene ontology Molecular function • basic amino acid transmembrane transporter activity • arginine transmembrane transporter activity • L-lysine transmembrane transporter activity • amino acid transmembrane transporter activity • GO:0022891 transmembrane transporter activity • L-ornithine transmembrane transporter activity Cellular component • integral component of membrane • membrane • cell membrane Biological process • arginine transport • basic amino acid transmembrane transport • L-lysine transmembrane transport • L-alpha-amino acid transmembrane transport • arginine transmembrane transport • amino acid transport • transmembrane transport • L-arginine import across plasma membrane • L-ornithine transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84889	11989
Ensembl	ENSG00000165349	ENSMUSG00000031297
UniProt	Q8WY07	P70423
RefSeq (mRNA)	NM_032803 NM_001048164	NM_001301840 NM_007515
RefSeq (protein)	NP_001041629 NP_116192	NP_001288769 NP_031541
Location (UCSC)	Chr X: 70.93 – 70.93 Mb	Chr X: 101.08 – 101.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

SLC7A3 is a member of the system y+ family of transporters characterized by sodium-independent transport of cationic amino acids.[supplied by OMIM][6]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000165349 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031297 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vekony N, Wolf S, Boissel JP, Gnauert K, Closs EI (Oct 2001). "Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues". Biochemistry. 40 (41): 12387–94. doi:10.1021/bi011345c. PMID 11591158.
6. "Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3".

Further reading

• Hosokawa H, Sawamura T, Kobayashi S, et al. (1997). "Cloning and characterization of a brain-specific cationic amino acid transporter". J. Biol. Chem. 272 (13): 8717–22. doi:10.1074/jbc.272.13.8717. PMID 9079705.
• Ito K, Groudine M (1997). "A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain". J. Biol. Chem. 272 (42): 26780–6. doi:10.1074/jbc.272.42.26780. PMID 9334265.
• Hosokawa H, Ninomiya H, Sawamura T, et al. (1999). "Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain". Brain Res. 838 (1–2): 158–65. doi:10.1016/S0006-8993(99)01686-8. PMID 10446328.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gilles W, Vulcu SD, Liewald JF, et al. (2005). "Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3". Biochim. Biophys. Acta. 1668 (2): 234–9. doi:10.1016/j.bbamem.2004.12.011. PMID 15737334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Rotmann A, Vékony N, Gassner D, et al. (2006). "Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane". Biochem. J. 395 (1): 117–23. doi:10.1042/BJ20051558. PMC 1409692. PMID 16332251.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.