IGSF2

Immunoglobulin superfamily, member 2 (IGSF2) also known as CD101 (Cluster of Differentiation 101), is a human gene.[4]

CD101
Identifiers
Aliases	CD101, EWI-101, IGSF2, V7, CD101 molecule
External IDs	OMIM: 604516 MGI: 2685862 HomoloGene: 3142 GeneCards: CD101
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.1 Start 117,001,750 bp[1] End 117,036,476 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Cellular component • cell membrane • extracellular exosome • membrane • integral component of membrane Biological process • cell surface receptor signaling pathway • positive regulation of myeloid leukocyte differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9398	630146
Ensembl	ENSG00000134256	n/a
UniProt	Q93033	A8E0Y8
RefSeq (mRNA)	NM_001256106 NM_001256109 NM_001256111 NM_004258	NM_001099332 NM_001167906
RefSeq (protein)	NP_001243035 NP_001243038 NP_001243040 NP_004249	NP_001161378
Location (UCSC)	Chr 1: 117 – 117.04 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000134256 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: IGSF2 immunoglobulin superfamily, member 2".

Further reading

• Rivas A, Ruegg CL, Zeitung J, et al. (1995). "V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies". J. Immunol. 154 (9): 4423–33. PMID 7722299.
• Ruegg CL, Rivas A, Madani ND, et al. (1995). "V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene". J. Immunol. 154 (9): 4434–43. PMID 7722300.
• Soares LR, Rivas A, Tsavaler L, Engleman EG (1997). "Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism". J. Immunol. 159 (3): 1115–24. PMID 9233604.
• Bagot M, Martinel I, Charue D, et al. (1998). "CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation". Tissue Antigens. 50 (5): 439–48. doi:10.1111/j.1399-0039.1997.tb02898.x. PMID 9389317.
• Soares LR, Tsavaler L, Rivas A, Engleman EG (1998). "V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation". J. Immunol. 161 (1): 209–17. PMID 9647226.
• Bouloc A, Boulland ML, Geissmann F, et al. (2000). "CD101 expression by Langerhans cell histiocytosis cells". Histopathology. 36 (3): 229–32. doi:10.1046/j.1365-2559.2000.00827.x. PMID 10692025.
• Bouloc A, Bagot M, Delaire S, et al. (2001). "Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production". Eur. J. Immunol. 30 (11): 3132–9. doi:10.1002/1521-4141(200011)30:11<3132::AID-IMMU3132>3.0.CO;2-E. PMID 11093127.
• Stipp CS, Kolesnikova TV, Hemler ME (2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J. Biol. Chem. 276 (44): 40545–54. doi:10.1074/jbc.M107338200. PMID 11504738.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Meyer N, Petrella T, Poszepczynska-Guigne E, et al. (2005). "CD4+ CD56+ blastic tumor cells express CD101 molecules". J. Invest. Dermatol. 124 (3): 668–9. doi:10.1111/j.0022-202X.2005.23617.x. PMID 15737213.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• IGSF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)