SLC17A3

Solute carrier family 17 (organic anion transporter), member 3 is a protein that in humans is encoded by the SLC17A3 gene.[5]

SLC17A3
Identifiers
Aliases	SLC17A3, NPT4, GOUT4, UAQTL4, solute carrier family 17 member 3
External IDs	OMIM: 611034 MGI: 2389216 HomoloGene: 21319 GeneCards: SLC17A3
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 25,833,066 bp[1] End 25,882,286 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,839,434 bp[2] End 23,860,716 bp[2]
Gene ontology Molecular function • efflux transmembrane transporter activity • voltage-gated anion channel activity • GO:0015238 xenobiotic transporter activity • toxin transporter activity • symporter activity • organic anion transmembrane transporter activity • sodium:phosphate symporter activity • urate transmembrane transporter activity • sialic acid transmembrane transporter activity Cellular component • brush border membrane • integral component of membrane • perinuclear region of cytoplasm • membrane • endoplasmic reticulum • integral component of plasma membrane • cell membrane • cytoplasm • endoplasmic reticulum membrane • apical plasma membrane • lysosome Biological process • sodium ion transport • sodium ion transmembrane transport • ion transmembrane transport • glucose-6-phosphate transport • organic anion transport • urate metabolic process • phosphate ion transport • urate transport • ion transport • drug transport • toxin transport • drug transmembrane transport • transmembrane transport • sialic acid transport • drug transmembrane export Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10786	105355
Ensembl	ENSG00000124564	ENSMUSG00000036083
UniProt	O00476	n/a
RefSeq (mRNA)	NM_006632 NM_001098486	NM_001164743 NM_134069
RefSeq (protein)	NP_001091956 NP_006623	n/a
Location (UCSC)	Chr 6: 25.83 – 25.88 Mb	Chr 13: 23.84 – 23.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum.[5]

See also

• Glycogen storage disease type I

References

1. GRCh38: Ensembl release 89: ENSG00000124564 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036083 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 17 (organic anion transporter), member 3".

Further reading

• Polasek O, Jeroncić I, Mulić R, Klismanic Z, Pehlić M, Zemunik T, Kolcić I (2010). "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series". Croat. Med. J. 51 (1): 32–9. doi:10.3325/cmj.2010.51.32. PMC 2829186. PMID 20162743.
• Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC, Coresh J, Fox CS (2008). "Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study". Lancet. 372 (9654): 1953–61. doi:10.1016/S0140-6736(08)61343-4. PMC 2803340. PMID 18834626.
• Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN (1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Res. 7 (5): 441–56. doi:10.1101/gr.7.5.441. PMID 9149941.
• Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, Fujita T, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H (2010). "Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate". J. Biol. Chem. 285 (45): 35123–32. doi:10.1074/jbc.M110.121301. PMC 2966126. PMID 20810651.
• Stark K, Reinhard W, Grassl M, Erdmann J, Schunkert H, Illig T, Hengstenberg C (2009). "Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease". PLOS ONE. 4 (11): e7729. Bibcode:2009PLoSO...4.7729S. doi:10.1371/journal.pone.0007729. PMC 2766838. PMID 19890391.
• Jutabha P, Anzai N, Kimura T, Taniguchi A, Urano W, Yamanaka H, Endou H, Sakurai H (2011). "Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms". J. Pharmacol. Sci. 115 (2): 249–53. doi:10.1254/jphs.10228sc. PMID 21282933.
• Melis D, Havelaar AC, Verbeek E, Smit GP, Benedetti A, Mancini GM, Verheijen F (2004). "NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic". J. Inherit. Metab. Dis. 27 (6): 725–33. doi:10.1023/B:BOLI.0000045755.89308.2f. PMID 15505377.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.