SLC22A2

Solute carrier family 22 member 2 (also termed OCT2 or organic cation transporter-2[5]) is a protein that in humans is encoded by the SLC22A2 gene.[6][7]

SLC22A2
Identifiers
Aliases	SLC22A2, OCT2, solute carrier family 22 member 2
External IDs	OMIM: 602608 MGI: 1335072 HomoloGene: 68293 GeneCards: SLC22A2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 160,171,061 bp[1] End 160,277,638 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 8.61 cM Start 12,584,132 bp[2] End 12,628,488 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0022891 transmembrane transporter activity • transporter activity • neurotransmitter transporter activity • quaternary ammonium group transmembrane transporter activity • organic cation transmembrane transporter activity • acetylcholine transmembrane transporter activity • GO:0005333 norepinephrine:sodium symporter activity • secondary active organic cation transmembrane transporter activity • organic anion transmembrane transporter activity Cellular component • integral component of membrane • membrane • cell membrane • extracellular exosome • integral component of plasma membrane • presynapse Biological process • drug transmembrane transport • body fluid secretion • quaternary ammonium group transport • neurotransmitter biosynthetic process • cation transport • ion transport • dopamine transport • GO:0010554 neurotransmitter secretion • organic cation transport • transmembrane transport • ammonium transmembrane transport • neurotransmitter transport • organic anion transport • norepinephrine transport • acetate ester transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6582	20518
Ensembl	ENSG00000112499	ENSMUSG00000040966
UniProt	O15244	O70577
RefSeq (mRNA)	NM_153191 NM_003058	NM_013667 NM_001355767
RefSeq (protein)	NP_003049	NP_038695 NP_001342696
Location (UCSC)	Chr 6: 160.17 – 160.28 Mb	Chr 17: 12.58 – 12.63 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.[7]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000112499 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040966 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "SLC22A2 solute carrier family 22 member 2 [Homo sapiens (human)] - Gene - NCBI".
6. Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet. 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850.
7. "Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2".

Further reading

• Berkhout B, Jeang KT (1992). "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat". J. Virol. 66 (1): 139–49. PMC 238269. PMID 1727476.
• Jeang KT, Chun R, Lin NH, et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. PMC 238044. PMID 7690421.
• Liu YZ, Lania L, Latchman DS (1997). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS. 10 (12): 1323–9. doi:10.1097/00002030-199610000-00003. PMID 8902060.
• Liu YZ, Latchman DS (1997). "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". Biochem. J. 322 (1): 155–8. doi:10.1042/bj3220155. PMC 1218171. PMID 9078256.
• Gorboulev V, Ulzheimer JC, Akhoundova A, et al. (1997). "Cloning and characterization of two human polyspecific organic cation transporters". DNA Cell Biol. 16 (7): 871–81. doi:10.1089/dna.1997.16.871. PMID 9260930.
• Busch AE, Karbach U, Miska D, et al. (1998). "Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine". Mol. Pharmacol. 54 (2): 342–52. doi:10.1124/mol.54.2.342. PMID 9687576.
• Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics. 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568.
• Gründemann D, Schömig E (2000). "Gene structures of the human non-neuronal monoamine transporters EMT and OCT2". Hum. Genet. 106 (6): 627–35. doi:10.1007/s004390050035. PMID 10942111.
• Pietig G, Mehrens T, Hirsch JR, et al. (2001). "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". J. Biol. Chem. 276 (36): 33741–6. doi:10.1074/jbc.M104617200. PMID 11447227.
• Boehm J, He Y, Greiner A, et al. (2001). "Regulation of BOB.1/OBF.1 stability by SIAH". EMBO J. 20 (15): 4153–62. doi:10.1093/emboj/20.15.4153. PMC 149152. PMID 11483518.
• Barendt WM, Wright SH (2002). "The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization". J. Biol. Chem. 277 (25): 22491–6. doi:10.1074/jbc.M203114200. PMID 11953440.
• Urakami Y, Akazawa M, Saito H, et al. (2002). "cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney". J. Am. Soc. Nephrol. 13 (7): 1703–10. doi:10.1097/01.ASN.0000019413.78751.46. PMID 12089365.
• Leabman MK, Huang CC, Kawamoto M, et al. (2003). "Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function". Pharmacogenetics. 12 (5): 395–405. doi:10.1097/00008571-200207000-00007. PMID 12142729.
• Cetinkaya I, Ciarimboli G, Yalçinkaya G, et al. (2003). "Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases". Am. J. Physiol. Renal Physiol. 284 (2): F293–302. doi:10.1152/ajprenal.00251.2002. PMID 12388397.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gründemann D, Hahne C, Berkels R, Schömig E (2003). "Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2)". J. Pharmacol. Exp. Ther. 304 (2): 810–7. doi:10.1124/jpet.102.044404. PMID 12538837.
• Bottalico B, Larsson I, Brodszki J, et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Placenta. 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.
• Lips KS, Volk C, Schmitt BM, et al. (2005). "Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium". Am. J. Respir. Cell Mol. Biol. 33 (1): 79–88. CiteSeerX 10.1.1.327.6767. doi:10.1165/rcmb.2004-0363OC. PMID 15817714.
• Jiang W, Prokopenko O, Wong L, et al. (2005). "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity". Mol. Cell. Biol. 25 (15): 6496–508. doi:10.1128/MCB.25.15.6496-6508.2005. PMC 1190334. PMID 16024787.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.