Glucose-6-phosphate exchanger SLC37A4

Glucose-6-phosphate exchanger SLC37A4, also known as glucose-6-phosphate translocase, is an enzyme that in humans is encoded by the SLC37A4 gene.[5][6][7]

SLC37A4
Identifiers
Aliases	SLC37A4, G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, TRG-19, TRG19, PRO0685, solute carrier family 37 member 4
External IDs	OMIM: 602671 MGI: 1316650 HomoloGene: 37482 GeneCards: SLC37A4
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 119,024,114 bp[1] End 119,030,906 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.2 Start 44,396,852 bp[2] End 44,402,968 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transporter activity • glucose-6-phosphate transmembrane transporter activity • glucose 6-phosphate:inorganic phosphate antiporter activity • antiporter activity • GO:0022891 transmembrane transporter activity Cellular component • integral component of membrane • membrane • integral component of endoplasmic reticulum membrane • endoplasmic reticulum • endoplasmic reticulum membrane Biological process • glucose-6-phosphate transport • phosphate ion transmembrane transport • glucose metabolic process • glucose homeostasis • carbohydrate transport • transmembrane transport • gluconeogenesis • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2542	14385
Ensembl	ENSG00000137700 ENSG00000281500	ENSMUSG00000032114
UniProt	O43826	n/a
RefSeq (mRNA)	NM_001467 NM_001164277 NM_001164278 NM_001164279 NM_001164280	NM_001293630 NM_001293631 NM_008063 NM_001357729 NM_001357730 NM_001378829 NM_001378830 NM_001378831 NM_001378832 NM_001378833 NM_001378834
RefSeq (protein)	NP_001157749 NP_001157750 NP_001157751 NP_001157752 NP_001458	n/a
Location (UCSC)	Chr 11: 119.02 – 119.03 Mb	Chr 9: 44.4 – 44.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. ENSG00000281500 GRCh38: Ensembl release 89: ENSG00000137700, ENSG00000281500 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032114 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gerin I, Veiga-da-Cunha M, Achouri Y, Collet JF, Van Schaftingen E (Jan 1998). "Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib". FEBS Lett. 419 (2–3): 235–8. doi:10.1016/S0014-5793(97)01463-4. PMID 9428641.
6. Annabi B, Hiraiwa H, Mansfield BC, Lei KJ, Ubagai T, Polymeropoulos MH, Moses SW, Parvari R, Hershkovitz E, Mandel H, Fryman M, Chou JY (Apr 1998). "The gene for glycogen-storage disease type 1b maps to chromosome 11q23". Am J Hum Genet. 62 (2): 400–5. doi:10.1086/301727. PMC 1376902. PMID 9463334.
7. "Entrez Gene: SLC37A4 Solute carrier family 37 (glycerol-6-phosphate transporter), member 4".

Further reading

• Chou JY, Matern D, Mansfield BC, Chen YT (2002). "Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex". Curr. Mol. Med. 2 (2): 121–43. doi:10.2174/1566524024605798. PMID 11949931.
• Narisawa K, Igarashi Y, Otomo H, Tada K (1978). "A new variant of glycogen storage disease type I probably due to a defect in the glucose-6-phosphate transport system". Biochem. Biophys. Res. Commun. 83 (4): 1360–4. doi:10.1016/0006-291X(78)91371-2. PMID 212064.
• Fenske CD, Jeffery S, Weber JL, et al. (1998). "Localisation of the gene for glycogen storage disease type 1c by homozygosity mapping to 11q". J. Med. Genet. 35 (4): 269–72. doi:10.1136/jmg.35.4.269. PMC 1051271. PMID 9598717.
• Kure S, Suzuki Y, Matsubara Y, et al. (1998). "Molecular analysis of glycogen storage disease type Ib: identification of a prevalent mutation among Japanese patients and assignment of a putative glucose-6-phosphate translocase gene to chromosome 11". Biochem. Biophys. Res. Commun. 248 (2): 426–31. doi:10.1006/bbrc.1998.8985. PMID 9675154.
• Veiga-da-Cunha M, Gerin I, Chen YT, et al. (1998). "A gene on chromosome 11q23 coding for a putative glucose- 6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic". Am. J. Hum. Genet. 63 (4): 976–83. doi:10.1086/302068. PMC 1377500. PMID 9758626.
• Marcolongo P, Barone V, Priori G, et al. (1998). "Structure and mutation analysis of the glycogen storage disease type 1b gene". FEBS Lett. 436 (2): 247–50. doi:10.1016/S0014-5793(98)01129-6. PMID 9781688.
• Lin B, Annabi B, Hiraiwa H, et al. (1998). "Cloning and characterization of cDNAs encoding a candidate glycogen storage disease type 1b protein in rodents". J. Biol. Chem. 273 (48): 31656–60. doi:10.1074/jbc.273.48.31656. PMID 9822626.
• Ihara K, Kuromaru R, Hara T (1998). "Genomic structure of the human glucose 6-phosphate translocase gene and novel mutations in the gene of a Japanese patient with glycogen storage disease type Ib". Hum. Genet. 103 (4): 493–6. doi:10.1007/s004390050856. PMID 9856496.
• Ihara K, Takabayashi A, Terasaki K, Hara T (1999). "Assignment1 of glucose 6-phosphate translocase (G6PT1) to human chromosome band 11q23.3 by in situ hybridization". Cytogenet. Cell Genet. 83 (1–2): 50–1. doi:10.1159/000015167. PMID 9925924.
• Gerin I, Veiga-da-Cunha M, Noël G, Van Schaftingen E (1999). "Structure of the gene mutated in glycogen storage disease type Ib". Gene. 227 (2): 189–95. doi:10.1016/S0378-1119(98)00614-3. PMID 10023055.
• Hiraiwa H, Pan CJ, Lin B, et al. (1999). "Inactivation of the glucose 6-phosphate transporter causes glycogen storage disease type 1b". J. Biol. Chem. 274 (9): 5532–6. doi:10.1074/jbc.274.9.5532. PMID 10026167.
• Pan CJ, Lin B, Chou JY (1999). "Transmembrane topology of human glucose 6-phosphate transporter". J. Biol. Chem. 274 (20): 13865–9. doi:10.1074/jbc.274.20.13865. PMID 10318794.
• Janecke AR, Bosshard NU, Mayatepek E, et al. (1999). "Molecular diagnosis of type 1c glycogen storage disease". Hum. Genet. 104 (3): 275–7. doi:10.1007/s004390050948. PMID 10323254.
• Hou DC, Kure S, Suzuki Y, et al. (1999). "Glycogen storage disease type Ib: structural and mutational analysis of the microsomal glucose-6-phosphate transporter gene". Am. J. Med. Genet. 86 (3): 253–7. doi:10.1002/(SICI)1096-8628(19990917)86:3<253::AID-AJMG11>3.0.CO;2-7. PMID 10482875.
• Veiga-da-Cunha M, Gerin I, Chen YT, et al. (1999). "The putative glucose 6-phosphate translocase gene is mutated in essentially all cases of glycogen storage disease type I non-a". Eur. J. Hum. Genet. 7 (6): 717–23. doi:10.1038/sj.ejhg.5200366. PMID 10482962.
• Galli L, Orrico A, Marcolongo P, et al. (1999). "Mutations in the glucose-6-phosphate transporter (G6PT) gene in patients with glycogen storage diseases type 1b and 1c". FEBS Lett. 459 (2): 255–8. doi:10.1016/S0014-5793(99)01248-X. PMID 10518030.
• Lam CW, Chan KY, Tong SF, et al. (2000). "A novel missense mutation (P191L) in the glucose-6-phosphate translocase gene identified in a Chinese family with glycogen storage disease 1b". Hum. Mutat. 16 (1): 94. doi:10.1002/1098-1004(200007)16:1<94::AID-HUMU26>3.0.CO;2-Q. PMID 10874322.
• Santer R, Rischewski J, Block G, et al. (2000). "Molecular analysis in glycogen storage disease 1 non-A: DHPLC detection of the highly prevalent exon 8 mutations of the G6PT1 gene in German patients". Hum. Mutat. 16 (2): 177. doi:10.1002/1098-1004(200008)16:2<177::AID-HUMU13>3.0.CO;2-8. PMID 10923042.