LILRA2

Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2 gene.[3][4][5]

LILRA2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2OTP
Identifiers
Aliases	LILRA2, CD85H, ILT1, LIR-7, LIR7, leukocyte immunoglobulin like receptor A2
External IDs	OMIM: 604812 HomoloGene: 68534 GeneCards: LILRA2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,572,920 bp[1] End 54,590,287 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • antigen binding • IgM binding • signaling receptor activity Cellular component • integral component of membrane • extracellular region • membrane • integral component of plasma membrane • cell membrane Biological process • defense response • signal transduction • immune system process • innate immune response activating cell surface receptor signaling pathway • neutrophil activation involved in immune response • negative regulation of lipopolysaccharide-mediated signaling pathway • granulocyte macrophage colony-stimulating factor production • interleukin-6 production • interleukin-8 production • negative regulation of toll-like receptor 4 signaling pathway • granulocyte colony-stimulating factor production • innate immune system • positive regulation of interleukin-1 beta secretion • positive regulation of cell activation • positive regulation of calcium ion transport • positive regulation of tumor necrosis factor secretion • positive regulation of interleukin-6 secretion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11027	n/a
Ensembl	ENSG00000239998 ENSG00000274000 ENSG00000275290 ENSG00000278634	n/a
UniProt	Q8N149	n/a
RefSeq (mRNA)	NM_001130917 NM_001290270 NM_001290271 NM_006866	n/a
RefSeq (protein)	NP_001124389 NP_001277199 NP_001277200 NP_006857	n/a
Location (UCSC)	Chr 19: 54.57 – 54.59 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM][5]

Function

LILRA2 senses microbially cleaved immunoglobulin to activate human myeloid cells.[6]

See also

• Cluster of differentiation

References

1. ENSG00000274000, ENSG00000275290, ENSG00000278634 GRCh38: Ensembl release 89: ENSG00000239998, ENSG00000274000, ENSG00000275290, ENSG00000278634 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806.
4. Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol. 159 (11): 5192–6. PMID 9548455.
5. "Entrez Gene: LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2".
6. Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nagai H, Nakamura Y, Katayama I, Colonna M, Arase H (Apr 2016). "LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins". Nature Microbiology. 1 (6): 16054. doi:10.1038/NMICROBIOL.2016.54.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Rojo S, Burshtyn DN, Long EO, Wagtmann N (1997). "Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells". J. Immunol. 158 (1): 9–12. PMID 8977169.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tedla N, Bandeira-Melo C, Tassinari P, et al. (2003). "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9. doi:10.1073/pnas.0337567100. PMC 298746. PMID 12529506.
• Nakajima H, Asai A, Okada A, et al. (2004). "Transcriptional regulation of ILT family receptors". J. Immunol. 171 (12): 6611–20. doi:10.4049/jimmunol.171.12.6611. PMID 14662864.
• Sloane DE, Tedla N, Awoniyi M, et al. (2004). "Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition". Blood. 104 (9): 2832–9. doi:10.1182/blood-2004-01-0268. PMID 15242876.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• LILRA2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.