Poliovirus receptor-related 3

Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions.[5]

NECTIN3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4FOM
Identifiers
Aliases	NECTIN3, CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRR3, PVRL3, nectin cell adhesion molecule 3
External IDs	OMIM: 607147 MGI: 1930171 HomoloGene: 9162 GeneCards: NECTIN3
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.13 Start 111,070,071 bp[1] End 111,275,563 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B5 Start 46,387,706 bp[2] End 46,498,525 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • GO:0001948 protein binding • receptor binding • cell adhesion molecule binding • identical protein binding • signaling receptor activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • intercellular junction • cell membrane • synapse • integral component of plasma membrane • cell junction • apical junction complex • cell-cell contact zone • hippocampal mossy fiber to CA3 synapse • integral component of postsynaptic density membrane • axon • dendrite Biological process • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • cell recognition • retina morphogenesis in camera-type eye • cell adhesion • lens morphogenesis in camera-type eye • fertilization • adherens junction organization • homophilic cell adhesion via plasma membrane adhesion molecules • spermatid development • protein localization to cell junction • cell-cell adhesion • establishment of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25945	58998
Ensembl	ENSG00000177707	ENSMUSG00000022656
UniProt	Q9NQS3	Q9JLB9
RefSeq (mRNA)	NM_001243286 NM_001243288 NM_015480	NM_021495 NM_021496 NM_021497
RefSeq (protein)	NP_001230215 NP_001230217 NP_056295	NP_067470 NP_067471 NP_067472
Location (UCSC)	Chr 3: 111.07 – 111.28 Mb	Chr 16: 46.39 – 46.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM][5]

Interactions

PVRL3 has been shown to interact with:

• MLLT4,[6][7]
• PARD3,[8]
• PTPRM.[9]

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000177707 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022656 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PVRL3 poliovirus receptor-related 3".
6. Satoh-Horikawa K, Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K, Mizoguchi A, Takai Y (April 2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell–cell adhesion activities". J. Biol. Chem. 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. PMID 10744716.
7. Reymond N, Borg JP, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P, Lopez M (September 2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene. 255 (2): 347–55. doi:10.1016/s0378-1119(00)00316-4. PMID 11024295.
8. Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (February 2003). "Direct binding of cell polarity protein PAR-3 to cell–cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.
9. Sakamoto Y, Ogita H, Komura H, Takai Y. "Involvement of nectin in inactivation of integrin alpha(v)beta(3) after the establishment of cell–cell adhesion". J. Biol. Chem. 283 (1): 496–505. doi:10.1074/jbc.M704195200. PMID 17965016.

Further reading

• Satoh-Horikawa K, Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K, Mizoguchi A, Takai Y (2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell–cell adhesion activities". J. Biol. Chem. 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. PMID 10744716.
• Reymond N, Borg JP, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P, Lopez M (2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene. 255 (2): 347–55. doi:10.1016/S0378-1119(00)00316-4. PMID 11024295.
• Fabre S, Reymond N, Cocchi F, Menotti L, Dubreuil P, Campadelli-Fiume G, Lopez M (2002). "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain". J. Biol. Chem. 277 (30): 27006–13. doi:10.1074/jbc.M203228200. PMID 12011057.
• Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (2003). "Direct binding of cell polarity protein PAR-3 to cell–cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.
• Mueller S, Wimmer E (2003). "Recruitment of nectin-3 to cell–cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains". J. Biol. Chem. 278 (33): 31251–60. doi:10.1074/jbc.M304166200. PMID 12759359.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Fujito T, Ikeda W, Kakunaga S, Minami Y, Kajita M, Sakamoto Y, Monden M, Takai Y (2005). "Inhibition of cell movement and proliferation by cell–cell contact-induced interaction of Necl-5 with nectin-3". J. Cell Biol. 171 (1): 165–73. doi:10.1083/jcb.200501090. PMC 2171219. PMID 16216929.

External links

• PVRL3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.