Zinc transporter ZIP6

Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.[5][6][7]

SLC39A6
Identifiers
Aliases	SLC39A6, LIV-1, ZIP6, solute carrier family 39 member 6
External IDs	OMIM: 608731 MGI: 2147279 HomoloGene: 8199 GeneCards: SLC39A6
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.2 Start 36,108,531 bp[1] End 36,129,385 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A2 Start 24,579,881 bp[2] End 24,603,817 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion transmembrane transporter activity • zinc ion transmembrane transporter activity Cellular component • integral component of membrane • cell surface • cell membrane • integral component of plasma membrane • lamellipodium membrane • endoplasmic reticulum • membrane Biological process • metal ion transport • zinc II ion transmembrane transport • zinc II ion transport • zinc II ion transmembrane import • ion transport • cellular zinc ion homeostasis • transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25800	106957
Ensembl	ENSG00000141424	ENSMUSG00000024270
UniProt	Q13433	Q8C145
RefSeq (mRNA)	NM_001099406 NM_012319	NM_139143
RefSeq (protein)	NP_001092876 NP_036451	NP_631882
Location (UCSC)	Chr 18: 36.11 – 36.13 Mb	Chr 18: 24.58 – 24.6 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM][7]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000141424 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024270 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Taylor KM, Nicholson RI (Mar 2003). "The LZT proteins; the LIV-1 subfamily of zinc transporters". Biochim Biophys Acta. 1611 (1–2): 16–30. doi:10.1016/S0005-2736(03)00048-8. PMID 12659941.
6. Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI (Sep 2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters". Biochem J. 375 (Pt 1): 51–9. doi:10.1042/BJ20030478. PMC 1223660. PMID 12839489.
7. "Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6".

Further reading

• Manning DL, Daly RJ, Lord PG, et al. (1988). "Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line". Mol. Cell. Endocrinol. 59 (3): 205–12. doi:10.1016/0303-7207(88)90105-0. PMID 2903103.
• Dressman MA, Walz TM, Lavedan C, et al. (2002). "Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies". Pharmacogenomics J. 1 (2): 135–41. doi:10.1038/sj.tpj.6500022. PMID 11911440.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Schaner ME, Ross DT, Ciaravino G, et al. (2004). "Gene expression patterns in ovarian carcinomas". Mol. Biol. Cell. 14 (11): 4376–86. doi:10.1091/mbc.E03-05-0279. PMC 266758. PMID 12960427.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kasper G, Weiser AA, Rump A, et al. (2005). "Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients". Int. J. Cancer. 117 (6): 961–73. doi:10.1002/ijc.21235. PMID 15986450.
• Zhao L, Chen W, Taylor KM, et al. (2007). "LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway". Biochem. Biophys. Res. Commun. 363 (1): 82–8. doi:10.1016/j.bbrc.2007.08.127. PMID 17825787.