SLC27A5

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene.[5][6][7]

SLC27A5
Identifiers
Aliases	SLC27A5, ACSB, ACSVL6, BACS, BAL, FACVL3, FATP-5, FATP5, VLACSR, VLCS-H2, VLCSH2, solute carrier family 27 member 5
External IDs	OMIM: 603314 MGI: 1347100 HomoloGene: 7596 GeneCards: SLC27A5
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.43 Start 58,479,512 bp[1] End 58,512,413 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 12,988,346 bp[2] End 12,998,192 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GO:0015246 fatty acid transmembrane transporter activity • cholate-CoA ligase activity • ligase activity • catalytic activity • very long-chain fatty acid-CoA ligase activity • ATP binding • long-chain fatty acid-CoA ligase activity • GO:0032403 macromolecular complex binding • GO:0005325 long-chain fatty acid transporter activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • integral component of endoplasmic reticulum membrane • basal plasma membrane • endoplasmic reticulum • macromolecular complex Biological process • lipid metabolism • very long-chain fatty acid metabolic process • fatty acid transport • fatty acid metabolic process • ketone body biosynthetic process • bile acid and bile salt transport • plasma membrane long-chain fatty acid transport • metabolism • long-chain fatty acid metabolic process • bile acid biosynthetic process • triglyceride mobilization • bile acid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10998	26459
Ensembl	ENSG00000083807	ENSMUSG00000030382
UniProt	Q9Y2P5	Q4LDG0
RefSeq (mRNA)	NM_012254 NM_001321196	NM_009512
RefSeq (protein)	NP_001308125 NP_036386	NP_033538
Location (UCSC)	Chr 19: 58.48 – 58.51 Mb	Chr 7: 12.99 – 13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog.[7]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000083807 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030382 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA (Oct 1999). "Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein". Mol Genet Metab. 68 (1): 32–42. doi:10.1006/mgme.1999.2883. PMID 10479480.
6. Steinberg SJ, Mihalik SJ, Kim DG, Cuebas DA, Watkins PA (Jun 2000). "The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase". J Biol Chem. 275 (21): 15605–8. doi:10.1074/jbc.C000015200. PMID 10749848.
7. "Entrez Gene: SLC27A5 solute carrier family 27 (fatty acid transporter), member 5".

Further reading

• Fisher E, Nitz I, Lindner I, et al. (2007). "Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation". Mol Nutr Food Res. 51 (2): 185–91. doi:10.1002/mnfr.200600162. PMID 17266179.
• Tu N, Hu Y, Mivechi NF (2006). "Heat shock transcription factor (Hsf)-4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins". J. Cell. Biochem. 98 (6): 1528–42. doi:10.1002/jcb.20865. PMID 16552721.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Mihalik SJ, Steinberg SJ, Pei Z, et al. (2002). "Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling". J. Biol. Chem. 277 (27): 24771–9. doi:10.1074/jbc.M203295200. PMID 11980911.
• Watkins PA, Pevsner J, Steinberg SJ (2000). "Human very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein". Prostaglandins Leukot. Essent. Fatty Acids. 60 (5–6): 323–8. doi:10.1016/S0952-3278(99)80007-6. PMID 10471116.
• Hirsch D, Stahl A, Lodish HF (1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8625–9. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.
• Berger J, Truppe C, Neumann H, Forss-Petter S (1998). "A novel relative of the very-long-chain acyl-CoA synthetase and fatty acid transporter protein genes with a distinct expression pattern". Biochem. Biophys. Res. Commun. 247 (2): 255–60. doi:10.1006/bbrc.1998.8770. PMID 9642112.