Zinc transporter 4

Zinc transporter 4 is a protein that in humans is encoded by the SLC30A4 gene.[4]

SLC30A4
Identifiers
Aliases	SLC30A4, ZNT4, znT-4, solute carrier family 30 member 4
External IDs	OMIM: 602095 MGI: 1345282 HomoloGene: 74984 GeneCards: SLC30A4
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.1|15q21.1 Start 45,479,606 bp[1] End 45,522,755 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cation transmembrane transporter activity • zinc ion transmembrane transporter activity • GO:0001948 protein binding Cellular component • cytoplasm • integral component of membrane • endosome • late endosome • membrane • late endosome membrane • lysosomal membrane • lysosome • endosome membrane • cell membrane Biological process • zinc ion homeostasis • zinc II ion transport • response to zinc ion • cation transport • ion transport • cation transmembrane transport • transmembrane transport • regulation of sequestering of zinc ion • response to toxic substance • zinc II ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7782	22785
Ensembl	ENSG00000104154	ENSMUSG00000005802
UniProt	O14863	O35149
RefSeq (mRNA)	NM_013309 NM_001321036	NM_001290993 NM_011774
RefSeq (protein)	NP_001307965 NP_037441	NP_001277922 NP_035904
Location (UCSC)	Chr 15: 45.48 – 45.52 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000104154 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: SLC30A4 solute carrier family 30 (zinc transporter), member 4".

Further reading

• Huang L, Gitschier J (1997). "A novel gene involved in zinc transport is deficient in the lethal milk mouse". Nat. Genet. 17 (3): 292–7. doi:10.1038/ng1197-292. PMID 9354792.
• Murgia C, Vespignani I, Cerase J, et al. (2000). "Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells". Am. J. Physiol. 277 (6 Pt 1): G1231–9. PMID 10600821.
• Küry S, Devilder MC, Avet-Loiseau H, et al. (2001). "Expression pattern, genomic structure and evaluation of the human SLC30A4 gene as a candidate for acrodermatitis enteropathica". Hum. Genet. 109 (2): 178–85. doi:10.1007/s004390100539. PMID 11511923.
• Bleck O, Ashton GH, Mallipeddi R, et al. (2002). "Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica". Arch. Dermatol. Res. 293 (8): 392–6. doi:10.1007/s004030100246. PMID 11686514.
• Nakano A, Nakano H, Hanada K, et al. (2002). "ZNT4 gene is not responsible for acrodermatitis enteropathica in Japanese families". Hum. Genet. 110 (2): 201–2. doi:10.1007/s00439-001-0661-7. PMID 11935329.
• Michalczyk AA, Allen J, Blomeley RC, Ackland ML (2002). "Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells". Biochem. J. 364 (Pt 1): 105–13. PMC 1222551. PMID 11988082.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Michalczyk A, Varigos G, Catto-Smith A, et al. (2003). "Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk". Hum. Genet. 113 (3): 202–10. doi:10.1007/s00439-003-0952-2. PMID 12743795.
• Henshall SM, Afar DE, Rasiah KK, et al. (2003). "Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer". Oncogene. 22 (38): 6005–12. doi:10.1038/sj.onc.1206797. PMID 12955079.
• Beck FW, Prasad AS, Butler CE, et al. (2004). "Differential expression of hZnT-4 in human prostate tissues". Prostate. 58 (4): 374–81. doi:10.1002/pros.10344. PMID 14968438.
• Ho LH, Ruffin RE, Murgia C, et al. (2004). "Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation". J. Immunol. 172 (12): 7750–60. doi:10.4049/jimmunol.172.12.7750. PMID 15187159.
• Smith JL, Xiong S, Markesbery WR, Lovell MA (2006). "Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain". Neuroscience. 140 (3): 879–88. doi:10.1016/j.neuroscience.2006.02.049. PMID 16580781.