CD79B

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.[4]

CD79B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KG5
Identifiers
Aliases	CD79B, AGM6, B29, IGB, CD79b molecule
External IDs	OMIM: 147245 MGI: 96431 HomoloGene: 521 GeneCards: CD79B
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.3 Start 63,928,740 bp[1] End 63,932,354 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • transmembrane signaling receptor activity • protein homodimerization activity • identical protein binding Cellular component • integral component of membrane • cell membrane • Golgi apparatus • integral component of plasma membrane • extracellular exosome • membrane • nucleoplasm • external side of plasma membrane • B cell receptor complex • cytoplasm • cytosol Biological process • cell surface receptor signaling pathway • adaptive immune response • immune response • signal transduction • immune system process • B cell differentiation • B cell receptor signaling pathway • protein homooligomerization • response to bacterium Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	974	15985
Ensembl	ENSG00000007312	n/a
UniProt	P40259	P15530
RefSeq (mRNA)	NM_000626 NM_001039933 NM_021602 NM_001329050	NM_008339 NM_001313939
RefSeq (protein)	NP_000617 NP_001035022 NP_001315979 NP_067613	NP_001300868 NP_032365
Location (UCSC)	Chr 17: 63.93 – 63.93 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

It is associated with agammaglobulinemia-6.

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.[4]

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000007312 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta".

Further reading

• Reth M (1992). "Antigen receptors on B lymphocytes". Annu. Rev. Immunol. 10: 97–121. doi:10.1146/annurev.iy.10.040192.000525. PMID 1591006.
• Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29". Eur. J. Immunol. 22 (6): 1621–5. doi:10.1002/eji.1830220641. PMID 1534761.
• Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex". Eur. J. Immunol. 24 (4): 812–6. doi:10.1002/eji.1830240406. PMID 7512031.
• Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex". Mol. Immunol. 31 (6): 419–27. doi:10.1016/0161-5890(94)90061-2. PMID 7514267.
• Brown VK, Ogle EW, Burkhardt AL, et al. (1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45". J. Biol. Chem. 269 (25): 17238–44. PMID 7516335.
• Rowley RB, Burkhardt AL, Chao HG, et al. (1995). "Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation". J. Biol. Chem. 270 (19): 11590–4. doi:10.1074/jbc.270.19.11590. PMID 7538118.
• Pani G, Kozlowski M, Cambier JC, et al. (1995). "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling". J. Exp. Med. 181 (6): 2077–84. doi:10.1084/jem.181.6.2077. PMC 2192043. PMID 7539038.
• Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunol. Lett. 44 (2–3): 97–103. doi:10.1016/0165-2478(94)00199-2. PMID 7541024.
• Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072–8. doi:10.1074/jbc.270.45.27072. PMID 7592958.
• Hashimoto S, Chiorazzi N, Gregersen PK (1995). "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells". Mol. Immunol. 32 (9): 651–9. doi:10.1016/0161-5890(95)00023-8. PMID 7643857.
• Hashimoto S, Chiorazzi N, Gregersen PK (1994). "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism". Immunogenetics. 40 (2): 145–9. doi:10.1007/BF00188178. PMID 7913081.
• Gold MR, Chiu R, Ingham RJ, et al. (1994). "Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes". J. Immunol. 153 (6): 2369–80. PMID 8077654.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hashimoto S, Gregersen PK, Chiorazzi N (1993). "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes". J. Immunol. 150 (2): 491–8. PMID 8419481.
• Wood WJ, Thompson AA, Korenberg J, et al. (1993). "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)". Genomics. 16 (1): 187–92. doi:10.1006/geno.1993.1157. PMID 8486355.
• Thompson AA, Wood WJ, Gilly MJ, et al. (1996). "The promoter and 5' flanking sequences controlling human B29 gene expression". Blood. 87 (2): 666–73. PMID 8555489.
• Astsaturov IA, Matutes E, Morilla R, et al. (1996). "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia". Leukemia. 10 (5): 769–73. PMID 8656670.
• Koyama M, Nakamura T, Higashihara M, et al. (1996). "The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing". Immunol. Lett. 47 (3): 151–6. doi:10.1016/0165-2478(95)00071-X. PMID 8747711.
• Carter RH, Doody GM, Bolen JB, Fearon DT (1997). "Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex". J. Immunol. 158 (7): 3062–9. PMID 9120258.

External links

• CD79B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CD79B genome location and CD79B gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human B-cell antigen receptor complex-associated protein beta chain (CD79B)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.