Solute carrier organic anion transporter family member 1B3

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.[5]

SLCO1B3
Identifiers
AliasesSLCO1B3, HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8, solute carrier organic anion transporter family member 1B3
External IDsOMIM: 605495 MGI: 1351899 HomoloGene: 75119 GeneCards: SLCO1B3
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p12.2Start20,810,702 bp[1]
End20,916,911 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

28234

28253

Ensembl

ENSG00000111700

ENSMUSG00000030236

UniProt

Q9NPD5

Q9JJL3

RefSeq (mRNA)

NM_019844
NM_001349920

NM_020495
NM_178235

RefSeq (protein)

NP_062818
NP_001336849

NP_065241

Location (UCSC)Chr 12: 20.81 – 20.92 MbChr 6: 141.63 – 141.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

Clinical significance

OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.[6] Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.[7]

In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.[7]

Substrates

Small molecules that are transported by SLCO1B3 include:[8]

gollark: Or any time, really.
gollark: There would be no photon torpedoes at this time.
gollark: ```Cold Ones (also ice giants, the Finality, Lords of the Last Waste)Mythological beings who dwell at the end of time, during the final blackness of the universe, the last surviving remnants of the war of all-against-all over the universe’s final stocks of extropy, long after the passing of baryonic matter and the death throes of the most ancient black holes. Savage, autocannibalistic beings, stretching their remaining existence across aeons-long slowthoughts powered by the rare quantum fluctuations of the nothingness, these wretched dead gods know nothing but despair, hunger, and envy for those past entities which dwelled in eras rich in energy differentials, information, and ordered states, and would – if they could – feast on any unwary enough to fall into their clutches.Stories of the Cold Ones are, of course, not to be interpreted literally: they are a philosophical and theological metaphor for the pessimal end-state of the universe, to wit, the final triumph of entropy in both a physical and a spiritual sense. Nonetheless, this metaphor has been adopted by both the Flamic church and the archai themselves to describe the potential future which it is their intention to avert.The Cold Ones have also found a place in popular culture, depicted as supreme villains: perhaps best seen in the Ghosts of the Dark Spiral expansion for Mythic Stars, a virtuality game from Nebula 12 ArGaming, ICC, and the Void Cascading InVid series, produced by Dexlyn Vithinios (Sundogs of Delphys, ICC).```
gollark: And it's all just horribly dense spaghetti code.
gollark: There are no docs or comments anywhere. It's ridiculous.

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000111700 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030236 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3".
  6. Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD (June 2008). "Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer". Clin. Cancer Res. 14 (11): 3312–8. doi:10.1158/1078-0432.CCR-07-4118. PMC 2701141. PMID 18519758.
  7. Heather Pressler; Tristan M. Sissung; David Venzon; Douglas K. Price; William D. Figg (May 2011). "Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression". Clin. Cancer Res. 6 (5): e20372. Bibcode:2011PLoSO...620372P. doi:10.1371/journal.pone.0020372. PMC 3098289. PMID 21625523.
  8. Hagenbuch B, Gui C (July 2008). "Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family". Xenobiotica. 38 (7–8): 778–801. doi:10.1080/00498250801986951. PMID 18668430.

Further reading


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