Y+L amino acid transporter 2

Y+L amino acid transporter 2, also known as cationic amino acid transporter, y+ system, is a protein that in humans is encoded by the SLC7A6 gene.[5][6]

SLC7A6
Identifiers
Aliases	SLC7A6, LAT-2, LAT3, y+LAT-2, solute carrier family 7 member 6
External IDs	OMIM: 605641 MGI: 2142598 HomoloGene: 62496 GeneCards: SLC7A6
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 68,264,516 bp[1] End 68,301,823 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 106,168,857 bp[2] End 106,198,706 bp[2]
Gene ontology Molecular function • L-amino acid transmembrane transporter activity • antiporter activity • amino acid transmembrane transporter activity • GO:0022891 transmembrane transporter activity Cellular component • integral component of membrane • basolateral plasma membrane • integral component of plasma membrane • membrane • cell membrane • intracellular membrane-bounded organelle Biological process • cellular amino acid metabolic process • amino acid transmembrane transport • amino acid transport • leukocyte migration • L-alpha-amino acid transmembrane transport • transmembrane transport • macromolecular complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9057	330836
Ensembl	ENSG00000103064	ENSMUSG00000031904
UniProt	Q92536	Q8BGK6
RefSeq (mRNA)	NM_001076785 NM_003983	NM_178798 NM_001357381 NM_001357382
RefSeq (protein)	NP_001070253 NP_003974 NP_001070253.1 NP_003974.3	NP_848913 NP_001344310 NP_001344311
Location (UCSC)	Chr 16: 68.26 – 68.3 Mb	Chr 8: 106.17 – 106.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Heterodimeric amino acid transporter

References

1. GRCh38: Ensembl release 89: ENSG00000103064 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031904 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".
6. Pfeiffer R, Rossier G, Spindler B, Meier C, Kühn L, Verrey F (January 1999). "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family". The EMBO Journal. 18 (1): 49–57. doi:10.1093/emboj/18.1.49. PMC 1171101. PMID 9878049.

Further reading

• Sekine Y, Nishibori Y, Akimoto Y, Kudo A, Ito N, Fukuhara D, Kurayama R, Higashihara E, Babu E, Kanai Y, Asanuma K, Nagata M, Majumdar A, Tryggvason K, Yan K (July 2009). "Amino acid transporter LAT3 is required for podocyte development and function". Journal of the American Society of Nephrology. 20 (7): 1586–96. doi:10.1681/ASN.2008070809. PMC 2709689. PMID 19443642.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Torrents D, Estévez R, Pineda M, Fernández E, Lloberas J, Shi YB, Zorzano A, Palacín M (December 1998). "Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance". The Journal of Biological Chemistry. 273 (49): 32437–45. doi:10.1074/jbc.273.49.32437. PMID 9829974.
• Bröer A, Wagner CA, Lang F, Bröer S (August 2000). "The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine". The Biochemical Journal. 349 Pt 3 (Pt 3): 787–95. PMC 1221206. PMID 10903140.
• Xu D, Hemler ME (August 2005). "Metabolic activation-related CD147-CD98 complex". Molecular & Cellular Proteomics. 4 (8): 1061–71. doi:10.1074/mcp.M400207-MCP200. PMC 1351277. PMID 15901826.