SLC26A8

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.[5][6][7]

SLC26A8
Identifiers
Aliases	SLC26A8, SPGF3, TAT1, solute carrier family 26 member 8
External IDs	OMIM: 608480 MGI: 2385046 HomoloGene: 27095 GeneCards: SLC26A8
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 35,943,516 bp[1] End 36,024,868 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 14.82 cM Start 28,637,783 bp[2] End 28,690,233 bp[2]
Gene ontology Molecular function • anion transmembrane transporter activity • anion:anion antiporter activity • sulfate transmembrane transporter activity • secondary active sulfate transmembrane transporter activity • bicarbonate transmembrane transporter activity • oxalate transmembrane transporter activity • GO:0001948 protein binding • chloride channel activity • chloride transmembrane transporter activity Cellular component • integral component of membrane • membrane • cell membrane • integral component of plasma membrane Biological process • flagellated sperm motility • cell differentiation • oxalate transport • sulfate transport • regulation of membrane potential • regulation of intracellular pH • ion transport • anion transport • multicellular organism development • bicarbonate transport • GO:0007126 meiotic cell cycle • transmembrane transport • spermatogenesis • sperm capacitation • chloride transport • chloride transmembrane transport • sulfate transmembrane transport • anion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116369	224661
Ensembl	ENSG00000112053	ENSMUSG00000036196
UniProt	Q96RN1	Q8R0C3
RefSeq (mRNA)	NM_001193476 NM_052961 NM_138718	NM_001290320 NM_146076
RefSeq (protein)	NP_001180405 NP_443193 NP_619732	NP_001277249
Location (UCSC)	Chr 6: 35.94 – 36.02 Mb	Chr 17: 28.64 – 28.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.[7]

Interactions

SLC26A8 has been shown to interact with RACGAP1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000112053 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036196 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (Apr 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". J. Biol. Chem. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.
6. Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (Feb 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics. 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.
7. "Entrez Gene: SLC26A8 solute carrier family 26, member 8".
8. Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (Jun 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.

Further reading

• Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495.
• Mäkelä S, Eklund R, Lähdetie J, Mikkola M, Hovatta O, Kere J (2005). "Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure". Mol. Hum. Reprod. 11 (2): 129–32. doi:10.1093/molehr/gah140. PMID 15579655.
• Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.
• Mocellin R, Bühlmeyer K (1975). "Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension". Eur J Cardiol. 3 (3): 205–11. PMID 1183472.