CSF2RB

CSF2RB (also known as cytokine receptor common subunit beta) is a common subunit to the following type I cytokine receptors:

• GM-CSF receptor
• IL-3 receptor
• IL-5 receptor.[5]

CSF2RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1C8P, 1EGJ, 1GH7, 2GYS, 4NKQ, 5DWU, 2NA9, 2NA8
Identifiers
Aliases	CSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, colony stimulating factor 2 receptor beta common subunit, betaGMR, colony stimulating factor 2 receptor subunit beta
External IDs	OMIM: 138981 MGI: 1339760 HomoloGene: 339 GeneCards: CSF2RB
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 36,913,628 bp[1] End 36,940,439 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.22 cM Start 78,282,507 bp[2] End 78,305,721 bp[2]
Gene ontology Molecular function • interleukin-3 receptor activity • interleukin-5 receptor activity • GO:0001948 protein binding • cytokine receptor activity • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • signaling receptor activity Cellular component • integral component of membrane • membrane • cell membrane • integral component of plasma membrane • granulocyte macrophage colony-stimulating factor receptor complex • intracellular Biological process • cellular protein metabolic process • respiratory gaseous exchange • MAPK cascade • signal transduction • response to lipopolysaccharide • peptidyl-tyrosine phosphorylation • interleukin-5-mediated signaling pathway • cellular response to interleukin-3 • interleukin-3-mediated signaling pathway • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1439	12984
Ensembl	ENSG00000100368	ENSMUSG00000071714
UniProt	P32927	P26954
RefSeq (mRNA)	NM_000395	NM_001287389 NM_007781
RefSeq (protein)	NP_000386	NP_001274318 NP_031807
Location (UCSC)	Chr 22: 36.91 – 36.94 Mb	Chr 15: 78.28 – 78.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000100368 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071714 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". The EMBO Journal. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

External links

• Cytokine+Receptor+Common+beta+Subunit at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P32927 (Human Cytokine receptor common subunit beta (CSF2RB)) at the PDBe-KB.