CD276

CD276 (Cluster of Differentiation 276) is a human protein encoded by the CD276 gene.[4]

CD276
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4I0K
Identifiers
Aliases	CD276, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2, CD276 molecule
External IDs	OMIM: 605715 MGI: 2183926 HomoloGene: 11892 GeneCards: CD276
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.1 Start 73,683,966 bp[1] End 73,714,514 bp[1]
Gene ontology Molecular function • GO:0001948 protein binding • receptor binding Cellular component • membrane • integral component of membrane • external side of plasma membrane Biological process • cellular proliferation • T cell activation • immune response • positive regulation of interferon-gamma biosynthetic process • positive regulation of T cell proliferation • regulation of immune response • T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80381	102657
Ensembl	ENSG00000103855	n/a
UniProt	Q5ZPR3	Q8VE98
RefSeq (mRNA)	NM_001024736 NM_025240 NM_001329628 NM_001329629	NM_133983
RefSeq (protein)	NP_001019907 NP_001316557 NP_001316558 NP_079516	NP_598744
Location (UCSC)	Chr 15: 73.68 – 73.71 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM][4]

CD276 (aka B7-H3), an immune checkpoint molecule, is expressed by some solid tumours and is the target of anticancer candidates such as MGA271.[5]

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000103855 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: CD276 CD276 molecule".
5. "Servier Pays MacroGenics $20M for Option to Anticancer Antibody - GEN". GEN.

Further reading

• Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K, Chen L (March 2001). "B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production". Nature Immunology. 2 (3): 269–74. doi:10.1038/85339. PMID 11224528.
• Sun M, Richards S, Prasad DV, Mai XM, Rudensky A, Dong C (June 2002). "Characterization of mouse and human B7-H3 genes". Journal of Immunology. 168 (12): 6294–7. doi:10.4049/jimmunol.168.12.6294. PMID 12055244.
• Ling V, Wu PW, Spaulding V, Kieleczawa J, Luxenberg D, Carreno BM, Collins M (September 2003). "Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss". Genomics. 82 (3): 365–77. doi:10.1016/S0888-7543(03)00126-5. PMID 12906861.
• Steinberger P, Majdic O, Derdak SV, Pfistershammer K, Kirchberger S, Klauser C, Zlabinger G, Pickl WF, Stöckl J, Knapp W (February 2004). "Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains". Journal of Immunology. 172 (4): 2352–9. doi:10.4049/jimmunol.172.4.2352. PMID 14764704.
• Zhang GB, Chen YJ, Shi Q, Ma HB, Ge Y, Wang Q, Jiang Z, Xu Y, Zhang XG (June 2004). "Human recombinant B7-H3 expressed in E. coli enhances T lymphocyte proliferation and IL-10 secretion in vitro". Acta Biochimica et Biophysica Sinica. 36 (6): 430–6. doi:10.1093/abbs/36.6.430. PMID 15188059.
• Castriconi R, Dondero A, Augugliaro R, Cantoni C, Carnemolla B, Sementa AR, Negri F, Conte R, Corrias MV, Moretta L, Moretta A, Bottino C (August 2004). "Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis". Proceedings of the National Academy of Sciences of the United States of America. 101 (34): 12640–5. doi:10.1073/pnas.0405025101. PMC 515110. PMID 15314238.
• Wang L, Fraser CC, Kikly K, Wells AD, Han R, Coyle AJ, Chen L, Hancock WW (February 2005). "B7-H3 promotes acute and chronic allograft rejection". European Journal of Immunology. 35 (2): 428–38. doi:10.1002/eji.200425518. PMID 15682454.
• Kim J, Myers AC, Chen L, Pardoll DM, Truong-Tran QA, Lane AP, McDyer JF, Fortuno L, Schleimer RP (September 2005). "Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells". American Journal of Respiratory Cell and Molecular Biology. 33 (3): 280–9. doi:10.1165/rcmb.2004-0129OC. PMC 2715317. PMID 15961727.
• Petroff MG, Kharatyan E, Torry DS, Holets L (August 2005). "The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta". The American Journal of Pathology. 167 (2): 465–73. doi:10.1016/S0002-9440(10)62990-2. PMC 1603571. PMID 16049332.
• Zhang G, Dong Q, Xu Y, Yu G, Zhang X (August 2005). "B7-H3: another molecule marker for Mo-DCs?". Cellular & Molecular Immunology. 2 (4): 307–11. PMID 16274630.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Sakthivel P, Wang X, Gharizadeh B, Giscombe R, Pirskanen R, Nyren P, Lefvert AK (December 2006). "Single-nucleotide polymorphisms in the B7H3 gene are not associated with human autoimmune myasthenia gravis". Journal of Genetics. 85 (3): 217–20. doi:10.1007/BF02935335. PMID 17406098.

External links

• CD276+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CD276 genome location and CD276 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q8VE98 (CD276 antigen) at the PDBe-KB.