Long-chain fatty acid transport protein 1

Long-chain fatty acid transport protein 1 (FATP1) is a protein that in humans is encoded by the SLC27A1 gene.[5][6]

SLC27A1
Identifiers
Aliases	SLC27A1, ACSVL5, FATP, FATP1, FATP-1, solute carrier family 27 member 1
External IDs	OMIM: 600691 MGI: 1347098 HomoloGene: 8063 GeneCards: SLC27A1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 17,468,769 bp[1] End 17,506,168 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 71,568,882 bp[2] End 71,587,302 bp[2]
Gene ontology Molecular function • long-chain fatty acid-CoA ligase activity • nucleotide binding • protein homodimerization activity • ligase activity • catalytic activity • very long-chain fatty acid-CoA ligase activity • GO:0015246 fatty acid transmembrane transporter activity • GO:0005325 long-chain fatty acid transporter activity • GO:0001948 protein binding Cellular component • cytoplasm • integral component of membrane • membrane • cell membrane • endoplasmic reticulum • endomembrane system • mitochondrion • mitochondrial inner membrane • cytosol • integral component of plasma membrane Biological process • phosphatidic acid biosynthetic process • phosphatidylserine biosynthetic process • lipid transport • lipid metabolism • medium-chain fatty acid transport • phosphatidylglycerol biosynthetic process • fatty acid transport • phosphatidylethanolamine biosynthetic process • adiponectin-activated signaling pathway • fatty acid metabolic process • positive regulation of protein serine/threonine kinase activity • response to insulin • negative regulation of phospholipid biosynthetic process • positive regulation of heat generation • cardiolipin biosynthetic process • phosphatidylinositol biosynthetic process • response to cold • phosphatidylcholine biosynthetic process • metabolism • long-chain fatty acid metabolic process • long-chain fatty acid transport • regulation of lipid metabolic process • transport • positive regulation of triglyceride biosynthetic process • long-chain fatty acid import Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	376497	26457
Ensembl	ENSG00000130304	ENSMUSG00000031808
UniProt	Q6PCB7	Q60714
RefSeq (mRNA)	NM_198580	NM_011977 NM_001357180 NM_001357181 NM_001357182
RefSeq (protein)	NP_940982	NP_036107 NP_001344109 NP_001344110 NP_001344111
Location (UCSC)	Chr 19: 17.47 – 17.51 Mb	Chr 8: 71.57 – 71.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Structure

The SLC27A1 gene is located on the 19th chromosome, with its specific location being 19p13.11. The gene contains 15 exons.[6] SLC27A1 encodes a 71.1 kDa protein that is composed of 646 amino acids; 26 peptides have been observed through mass spectrometry data.[7][8]

See also

• SLC27A1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000130304 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031808 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Martin G, Nemoto M, Gelman L, Geffroy S, Najib J, Fruchart JC, Roevens P, de Martinville B, Deeb S, Auwerx J (June 2000). "The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression". Genomics. 66 (3): 296–304. doi:10.1006/geno.2000.6191. PMID 10873384.
6. "Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1".
7. ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (October 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
8. "Long-chain fatty acid transport protein 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).

Further reading

• Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J (2006). "Lack of association between certain candidate gene polymorphisms and the metabolic syndrome". Molecular Genetics and Metabolism. 86 (1–2): 293–9. doi:10.1016/j.ymgme.2005.05.006. PMID 15978856.
• García-Martínez C, Marotta M, Moore-Carrasco R, Guitart M, Camps M, Busquets S, Montell E, Gómez-Foix AM (June 2005). "Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells". American Journal of Physiology. Cell Physiology. 288 (6): C1264-72. doi:10.1152/ajpcell.00271.2004. PMID 15897321.
• Gertow K, Skoglund-Andersson C, Eriksson P, Boquist S, Orth-Gomér K, Schenck-Gustafsson K, Hamsten A, Fisher RM (April 2003). "A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution". Atherosclerosis. 167 (2): 265–73. doi:10.1016/S0021-9150(02)00454-9. PMID 12818409.
• Hatch GM, Smith AJ, Xu FY, Hall AM, Bernlohr DA (September 2002). "FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells". Journal of Lipid Research. 43 (9): 1380–9. doi:10.1194/jlr.M200130-JLR200. PMID 12235169.
• Hirsch D, Stahl A, Lodish HF (July 1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8625–9. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.
• Schaffer JE, Lodish HF (November 1994). "Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein". Cell. 79 (3): 427–36. doi:10.1016/0092-8674(94)90252-6. PMID 7954810.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.