Zinc transporter 1

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.[4][5]

SLC30A1
Identifiers
Aliases	SLC30A1, ZNT1, ZRC1, solute carrier family 30 member 1
External IDs	OMIM: 609521 MGI: 1345281 HomoloGene: 6681 GeneCards: SLC30A1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.3 Start 211,571,568 bp[1] End 211,579,161 bp[1]
Gene ontology Molecular function • calcium channel inhibitor activity • cation transmembrane transporter activity • GO:0001948 protein binding • zinc ion transmembrane transporter activity Cellular component • cytoplasm • integral component of membrane • Golgi apparatus • nuclear membrane • membrane • T-tubule • cell membrane • endoplasmic reticulum • Schaffer collateral - CA1 synapse • integral component of postsynaptic density membrane Biological process • negative regulation of neurotransmitter secretion • calcium ion import • zinc II ion transport • cellular calcium ion homeostasis • response to zinc ion • cation transport • in utero embryonic development • ion transport • negative regulation of calcium ion import • detoxification of cadmium ion • negative regulation of zinc ion transmembrane import • zinc II ion transmembrane transport • cellular zinc ion homeostasis • cadmium ion transmembrane transport • regulation of sequestering of zinc ion • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7779	22782
Ensembl	ENSG00000170385	ENSMUSG00000037434
UniProt	Q9Y6M5	Q60738
RefSeq (mRNA)	NM_021194	NM_009579
RefSeq (protein)	NP_067017	NP_033605
Location (UCSC)	Chr 1: 211.57 – 211.58 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn⁺⁺ influx, but also Ca⁺⁺ influx, thereby protecting cells from the effects of excessive cation permeation.[6]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000170385 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal. 14 (4): 639–49. doi:10.1002/j.1460-2075.1995.tb07042.x. PMC 398127. PMID 7882967.
5. Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics. 5 (1): 32. doi:10.1186/1471-2164-5-32. PMC 428573. PMID 15154973.
6. Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications. 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416.

Further reading

• Guey LT, GarcÃa-Closas M, Murta-Nascimento C, et al. (2009). "Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes". Eur. Urol. 57 (2): 283–292. doi:10.1016/j.eururo.2009.08.001. PMC 3220186. PMID 19692168.
• Zhang LH, Wang X, Stoltenberg M, et al. (2008). "Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain". Brain Res. Bull. 77 (1): 55–60. doi:10.1016/j.brainresbull.2008.03.014. PMID 18639746.
• Lovell MA, Smith JL, Xiong S, Markesbery WR (2005). "Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease". Neurotoxicity Research. 7 (4): 265–71. doi:10.1007/BF03033884. PMID 16179263.
• Zhang LY, Wang XL, Sun DX, et al. (2008). "Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts". Mol. Biol. Rep. 35 (4): 595–600. doi:10.1007/s11033-007-9129-8. PMID 17786585.
• Iguchi K, Otsuka T, Usui S, et al. (2004). "Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells". J. Androl. 25 (1): 154–61. doi:10.1002/j.1939-4640.2004.tb02771.x. PMID 14662799.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lazarczyk M, Pons C, Mendoza JA, et al. (2008). "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses". J. Exp. Med. 205 (1): 35–42. doi:10.1084/jem.20071311. PMC 2234378. PMID 18158319.
• Overbeck S, Uciechowski P, Ackland ML, et al. (2008). "Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9". J. Leukoc. Biol. 83 (2): 368–80. doi:10.1189/jlb.0307148. PMID 17971500.
• Hosgood HD, Menashe I, He X, et al. (2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respiratory Medicine. 103 (12): 1866–1870. doi:10.1016/j.rmed.2009.06.016. PMC 2783799. PMID 19625176.
• Hosgood HD, Menashe I, Shen M, et al. (2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway". Carcinogenesis. 29 (10): 1938–43. doi:10.1093/carcin/bgn178. PMC 2722857. PMID 18676680.
• Etzion Y, Ganiel A, Beharier O, et al. (2008). "Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study". J. Cardiovasc. Electrophysiol. 19 (2): 157–64. doi:10.1111/j.1540-8167.2007.01008.x. PMID 17971132.
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.