CMP-sialic acid transporter

CMP-sialic acid transporter is a protein that in humans is encoded by the SLC35A1 gene.[5][6][7]

SLC35A1
Identifiers
Aliases	SLC35A1, CDG2F, CMPST, CST, hCST, Solute carrier family 35 (CMP-sialic acid transporter), member A1, solute carrier family 35 member A1
External IDs	OMIM: 605634 MGI: 1345622 HomoloGene: 38181 GeneCards: SLC35A1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 87,470,623 bp[1] End 87,512,336 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 34,663,257 bp[2] End 34,687,438 bp[2]
Gene ontology Molecular function • CMP-N-acetylneuraminate transmembrane transporter activity • pyrimidine nucleotide-sugar transmembrane transporter activity • sialic acid transmembrane transporter activity Cellular component • integral component of membrane • Golgi membrane • Golgi apparatus • integral component of plasma membrane • membrane • integral component of Golgi membrane Biological process • CMP-N-acetylneuraminate transport • cellular protein modification process • carbohydrate transport • carbohydrate metabolic process • pyrimidine nucleotide-sugar transmembrane transport • sialic acid transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10559	24060
Ensembl	ENSG00000164414	ENSMUSG00000028293
UniProt	P78382	Q61420
RefSeq (mRNA)	NM_006416 NM_001168398	NM_011895
RefSeq (protein)	NP_001161870 NP_006407	NP_036025
Location (UCSC)	Chr 6: 87.47 – 87.51 Mb	Chr 4: 34.66 – 34.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000164414 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028293 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishida N, Miura N, Yoshioka S, Kawakita M (Apr 1997). "Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family". J Biochem. 120 (6): 1074–8. doi:10.1093/oxfordjournals.jbchem.a021523. PMID 9010752.
6. Ishida N, Ito M, Yoshioka S, Sun-Wada GH, Kawakita M (Sep 1998). "Functional expression of human golgi CMP-sialic acid transporter in the Golgi complex of a transporter-deficient Chinese hamster ovary cell mutant". J Biochem. 124 (1): 171–8. doi:10.1093/oxfordjournals.jbchem.a022076. PMID 9644260.
7. "Entrez Gene: SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1".

Further reading

• Wahlberg JE (1976). "Sensitization and testing of guinea pigs with nickel sulfate". Dermatologica. 152 (6): 321–30. doi:10.1159/000251278. PMID 964426.
• Harvey BE, Thomas P (1993). "Inhibition of CMP-sialic acid transport in human liver and colorectal cancer cell lines by a sialic acid nucleoside conjugate (KI-8110)". Biochem. Biophys. Res. Commun. 190 (2): 571–5. doi:10.1006/bbrc.1993.1086. PMID 8427599.
• Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression". Genomics. 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Aoki K, Ishida N, Kawakita M (2003). "Substrate recognition by nucleotide sugar transporters: further characterization of substrate recognition regions by analyses of UDP-galactose/CMP-sialic acid transporter chimeras and biochemical analysis of the substrate specificity of parental and chimeric transporters". J. Biol. Chem. 278 (25): 22887–93. doi:10.1074/jbc.M302620200. PMID 12682060.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Martinez-Duncker I, Dupré T, Piller V, et al. (2005). "Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter". Blood. 105 (7): 2671–6. doi:10.1182/blood-2004-09-3509. PMID 15576474.
• Misaki R, Fujiyama K, Seki T (2006). "Expression of human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid transporter in tobacco suspension-cultured cell". Biochem. Biophys. Res. Commun. 339 (4): 1184–9. doi:10.1016/j.bbrc.2005.11.130. PMID 16343442.
• Zhao W, Chen TL, Vertel BM, Colley KJ (2006). "The CMP-sialic acid transporter is localized in the medial-trans Golgi and possesses two specific endoplasmic reticulum export motifs in its carboxyl-terminal cytoplasmic tail". J. Biol. Chem. 281 (41): 31106–18. doi:10.1074/jbc.M605564200. PMID 16923816.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview