Vesicular glutamate transporter 1

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.[5][6][7]

SLC17A7
Identifiers
AliasesSLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDsOMIM: 605208 MGI: 1920211 HomoloGene: 113454 GeneCards: SLC17A7
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.33Start49,429,401 bp[1]
End49,442,360 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

57030

72961

Ensembl

ENSG00000104888

ENSMUSG00000070570

UniProt

Q9P2U7

Q3TXX4

RefSeq (mRNA)

NM_020309

NM_182993

RefSeq (protein)

NP_064705

NP_892038

Location (UCSC)Chr 19: 49.43 – 49.44 MbChr 7: 45.16 – 45.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000104888 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000070570 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143.
  6. Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226.
  7. "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.