CD160

CD160 antigen is a protein that in humans is encoded by the CD160 gene.[5][6][7]

CD160
Identifiers
Aliases	CD160, BY55, NK1, NK28, CD160 molecule
External IDs	OMIM: 604463 MGI: 1860383 HomoloGene: 5122 GeneCards: CD160
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 145,719,471 bp[1] End 145,739,288 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 96,798,763 bp[2] End 96,829,351 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor binding • GO:0001948 protein binding • MHC class I receptor activity • signaling receptor activity Cellular component • anchored component of membrane • anchored component of plasma membrane • cell membrane • membrane Biological process • cellular defense response • cell surface receptor signaling pathway • cellular proliferation • defense response to Gram-negative bacterium • regulation of immune response • negative regulation of angiogenesis • positive regulation of endothelial cell apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11126	54215
Ensembl	ENSG00000117281	ENSMUSG00000038304
UniProt	O95971	O88875
RefSeq (mRNA)	NM_007053	NM_001163496 NM_001163497 NM_018767
RefSeq (protein)	NP_008984	NP_001156968 NP_001156969 NP_061237
Location (UCSC)	Chr 1: 145.72 – 145.74 Mb	Chr 3: 96.8 – 96.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

CD160 is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.[7]

Clinical significance

CD160 is a ligand for HVEM, and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti- PD-1 antibodies.[8] CD160 has also been proposed as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.[9]

Related gene problems

• TAR syndrome[10]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000117281 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038304 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ (Oct 1998). "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes". J Immunol. 161 (6): 2780–90. PMID 9743336.
6. Agrawal S, Marquet J, Freeman GJ, Tawab A, Bouteiller PL, Roth P, Bolton W, Ogg G, Boumsell L, Bensussan A (Apr 1999). "Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells". J Immunol. 162 (3): 1223–6. PMID 9973372.
7. "Entrez Gene: CD160 CD160 molecule".
8. Stecher, Carmen; Battin, Claire; Leitner, Judith; Zettl, Markus; Grabmeier-Pfistershammer, Katharina; H?ller, Christoph; Zlabinger, Gerhard J.; Steinberger, Peter (22 May 2017). "PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells". Frontiers in Immunology. 8. doi:10.3389/fimmu.2017.00572. PMC 5439058. PMID 28588576.
9. Chabot, Sophie; Jabrane-Ferrat, Nabila; Bigot, Karine; Tabiasco, Julie; Provost, Alexandra; Golzio, Muriel; Noman, Muhammad Zaeem; Giustiniani, J?r?me; Bellard, Elisabeth; Brayer, St?phanie; Aguerre-Girr, Maryse; Meggetto, Fabienne; Giuriato, Sylvie; Malecaze, Fran?ois; Galiacy, St?phane; Ja?s, Jean-Philippe; Chose, Olivier; Kadouche, Jean; Chouaib, Salem; Teissi?, Justin; Abitbol, Marc; Bensussan, Armand; Le Bouteiller, Philippe (9 May 2011). "A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor". The Journal of Experimental Medicine. 208 (5): 973–986. doi:10.1084/jem.20100810. PMC 3092350. PMID 21482699.
10. Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading

• Bensussan A, Gluckman E, el Marsafy S, et al. (1994). "BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity". Proc. Natl. Acad. Sci. U.S.A. 91 (19): 9136–40. doi:10.1073/pnas.91.19.9136. PMC 44762. PMID 8090781.
• Nikolova M, Marie-Cardine A, Boumsell L, Bensussan A (2002). "BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression". Int. Immunol. 14 (5): 445–51. doi:10.1093/intimm/14.5.445. PMID 11978774.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tanaka J, Toubai T, Tsutsumi Y, et al. (2004). "Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells". Blood. 104 (3): 768–74. doi:10.1182/blood-2003-11-3870. PMID 15073036.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barakonyi A, Rabot M, Marie-Cardine A, et al. (2004). "Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset". J. Immunol. 173 (9): 5349–54. doi:10.4049/jimmunol.173.9.5349. PMID 15494480.
• Abecassis S, Giustiniani J, Meyer N, et al. (2007). "Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation". J. Invest. Dermatol. 127 (5): 1161–6. doi:10.1038/sj.jid.5700680. PMID 17218942.
• Giustiniani J, Marie-Cardine A, Bensussan A (2007). "A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity". J. Immunol. 178 (3): 1293–300. doi:10.4049/jimmunol.178.3.1293. PMID 17237375.

External links

• CD160+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CD160 genome location and CD160 gene details page in the UCSC Genome Browser.