Latrophilin
Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind the spider venom alpha-latrotoxin.[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans.[2]
| Latrophilin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Latrophilin | ||||||||
| Pfam | PF02354 | ||||||||
| InterPro | IPR003334 | ||||||||
| |||||||||
| EGF, latrophilin and seven transmembrane domain containing 1 | |
|---|---|
| Identifiers | |
| Symbol | ELTD1 |
| Alt. symbols | ETL |
| NCBI gene | 64123 |
| HGNC | 20822 |
| RefSeq | NM_022159 |
| UniProt | Q9HBW9 |
| Other data | |
| Locus | Chr. 1 p33-p32 |
| latrophilin 1 | |
|---|---|
| Identifiers | |
| Symbol | LPHN1 |
| Alt. symbols | KIAA0821, CIRL1, LEC2 |
| NCBI gene | 22859 |
| HGNC | 20973 |
| RefSeq | NM_014921 |
| UniProt | O94910 |
| Other data | |
| Locus | Chr. 19 p13.2 |
| latrophilin 2 | |
|---|---|
| Identifiers | |
| Symbol | LPHN2 |
| Alt. symbols | LPHH1, KIAA0786, LEC1 |
| NCBI gene | 23266 |
| HGNC | 18582 |
| OMIM | 607018 |
| RefSeq | NM_012302 |
| UniProt | O95490 |
| Other data | |
| Locus | Chr. 1 p31.1 |
| latrophilin 3 | |
|---|---|
| Identifiers | |
| Symbol | LPHN3 |
| Alt. symbols | KIAA0768, LEC3 |
| NCBI gene | 23284 |
| HGNC | 20974 |
| RefSeq | NM_015236 |
| UniProt | Q9HAR2 |
| Other data | |
| Locus | Chr. 4 q13.1 |
The precise functions of latrophilins remain unknown.[2] Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer.[3]
Human proteins containing this domain
gollark: You're esobot.
gollark: I KNEW IT
gollark: IT BECAME SENTIENT
gollark: ESOBOT DID IT
gollark: How would palaiologos do it?
See also
References
- Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). "Interaction of G-protein-coupled receptors with synaptic scaffolding proteins". Biochem. Soc. Trans. 30 (4): 464–8. doi:10.1042/BST0300464. PMID 12196116.
- Silva, JP; Ushkaryov, YA (2010). "The latrophilins, "split-personality" receptors". Advances in Experimental Medicine and Biology. 706: 59–75. doi:10.1007/978-1-4419-7913-1_5. PMC 3145135. PMID 21618826.
- Meza-Aguilar, Diana G; Boucard, Antony A (1 January 2014). "Latrophilins updated". Biomolecular Concepts. 5 (6). doi:10.1515/bmc-2014-0032.
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