GNRHR2

Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2 gene.[2][3]

GNRHR2
Identifiers
AliasesGNRHR2, GnRH-II-R, gonadotropin releasing hormone receptor 2 (pseudogene)
External IDsGeneCards: GNRHR2
Orthologs
SpeciesHumanMouse
Entrez

114814

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Ensembl

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UniProt

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RefSeq (mRNA)

NM_057163
NM_206994

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Function

The receptor for gonadotropin releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in human, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In human, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.[3]

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See also

References
  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. Faurholm B, Millar RP, Katz AA (Nov 2001). "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci". Genomics. 78 (1–2): 15–8. doi:10.1006/geno.2001.6650. PMID 11707068.
  3. "Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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