FZD8

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.[4][5]

FZD8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IJY, 4F0A
Identifiers
Aliases	FZD8, FZ-8, hFZ8, frizzled class receptor 8
External IDs	OMIM: 606146 MGI: 108460 HomoloGene: 40606 GeneCards: FZD8
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p11.21 Start 35,638,249 bp[1] End 35,642,278 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transmembrane signaling receptor activity • receptor binding • ubiquitin protein ligase binding • GO:0001948 protein binding • signal transducer activity • PDZ domain binding • G-protein coupled receptor activity • Wnt-protein binding • Wnt-activated receptor activity Cellular component • integral component of membrane • membrane • cell membrane • Golgi apparatus • Wnt-Frizzled-LRP5/6 complex Biological process • positive regulation of protein phosphorylation • positive regulation of JUN kinase activity • cell surface receptor signaling pathway • G-protein coupled receptor signaling pathway • angiogenesis • positive regulation of transcription from RNA polymerase II promoter • multicellular organism development • negative regulation of transcription from RNA polymerase II promoter • neuron differentiation • signal transduction • Wnt signaling pathway • T cell differentiation in thymus • non-canonical Wnt signaling pathway • canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8325	14370
Ensembl	ENSG00000177283	n/a
UniProt	Q9H461	Q61091
RefSeq (mRNA)	NM_031866	NM_008058
RefSeq (protein)	NP_114072	NP_032084
Location (UCSC)	Chr 10: 35.64 – 35.64 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[5]

See also

• Frizzled

References

1. GRCh38: Ensembl release 89: ENSG00000177283 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol. 18 (5): 991–6. doi:10.3892/ijo.18.5.991. PMID 11295046.
5. "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)".

Further reading

• Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem. 271 (8): 4468–4476. doi:10.1074/jbc.271.8.4468. PMID 8626800.
• Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–6775. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
• Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530–535. doi:10.1038/35035117. PMID 11029007.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–961. doi:10.1016/S0960-9822(01)00290-1. PMID 11448771.
• Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ (2001). "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains". Nature. 412 (6842): 86–90. doi:10.1038/35083601. PMID 11452312.
• Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem. Biophys. Res. Commun. 286 (4): 771–778. doi:10.1006/bbrc.2001.5430. PMID 11520064.
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
• Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth". Cell. 119 (1): 97–108. doi:10.1016/j.cell.2004.09.019. PMID 15454084.

External links

• "Frizzled Receptors: FZD₈". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Overview of all the structural information available in the PDB for UniProt: Q9H461 (Human Frizzled-8 (FZD8)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.