Relaxin/insulin-like family peptide receptor 4

RXFP4
Identifiers
Aliases	RXFP4, GPCR142, GPR100, RLN3R2, RXFPR4, Relaxin/insulin-like family peptide receptor 4, relaxin/insulin like family peptide receptor 4, relaxin family peptide/INSL5 receptor 4
External IDs	OMIM: 609043 MGI: 2182926 HomoloGene: 18775 GeneCards: RXFP4
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	155,942,949 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	88,653,142 bp[2]
Gene ontology
Molecular function	• GO:0001948 protein binding; • G-protein coupled receptor activity; • signal transducer activity; • galanin receptor activity; • G-protein coupled peptide receptor activity;
Cellular component	• integral component of membrane; • cell membrane; • integral component of plasma membrane; • membrane;
Biological process	• phospholipase C-activating G-protein coupled receptor signaling pathway; • positive regulation of feeding behavior; • signal transduction; • adenylate cyclase-modulating G-protein coupled receptor signaling pathway; • neuropeptide signaling pathway; • G-protein coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	339403
	242093
	ENSG00000173080
	ENSMUSG00000049741
	Q8TDU9
	Q7TQP4
	NM_181885
	NM_181817
	NP_871001
	NP_861538
	Wikidata
View/Edit Human	View/Edit Mouse

Relaxin/insulin-like family peptide receptor 4, also known as RXFP4, is a human G-protein coupled receptor.[5]

Function

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by OMIM][5]

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References

GRCh38: Ensembl release 89: ENSG00000173080 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000049741 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4".

External links

"Relaxin Family Peptide Receptors: RXFP4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (May 2005). "Receptors for relaxin family peptides". Annals of the New York Academy of Sciences. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688.
Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (March 2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacological Reviews. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880.
Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
Liu C, Chen J, Sutton S, Roland B, Kuei C, Farmer N, Sillard R, Lovenberg TW (December 2003). "Identification of relaxin-3/INSL7 as a ligand for GPCR142". The Journal of Biological Chemistry. 278 (50): 50765–70. doi:10.1074/jbc.M308996200. PMID 14522967.
Boels K, Schaller HC (November 2003). "Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor". British Journal of Pharmacology. 140 (5): 932–8. doi:10.1038/sj.bjp.0705521. PMC 1574110. PMID 14530218.
Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (November 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Letters. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098.
Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW (January 2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Molecular Pharmacology. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925.
Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J, Wilkinson T, Bathgate R, Eriste E, Sillard R, Lovenberg TW (January 2005). "INSL5 is a high affinity specific agonist for GPCR142 (GPR100)". The Journal of Biological Chemistry. 280 (1): 292–300. doi:10.1074/jbc.M409916200. PMID 15525639.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173080 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049741 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4".

Relaxin/insulin-like family peptide receptor 4

Function

See also

References

External links

Further reading