LPAR4

Lysophosphatidic acid receptor 4 also known as LPA₄ is a protein that in humans is encoded by the LPAR4 gene.[5][6][7] LPA₄ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[8]

LPAR4
Identifiers
Aliases	LPAR4, GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9, lysophosphatidic acid receptor 4
External IDs	OMIM: 300086 MGI: 1925384 HomoloGene: 3871 GeneCards: LPAR4
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.1 Start 78,747,709 bp[1] End 78,757,094 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 106,920,625 bp[2] End 106,933,900 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • lysophosphatidic acid binding • signal transducer activity • lipid binding • G-protein coupled receptor activity • lysophosphatidic acid receptor activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • cell membrane • nuclear body • intracellular membrane-bounded organelle Biological process • signal transduction • positive regulation of Rho protein signal transduction • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2846	78134
Ensembl	ENSG00000147145	ENSMUSG00000049929
UniProt	Q99677	Q8BLG2
RefSeq (mRNA)	NM_001278000 NM_005296	NM_175271
RefSeq (protein)	NP_001264929 NP_005287	NP_780480
Location (UCSC)	Chr X: 78.75 – 78.76 Mb	Chr X: 106.92 – 106.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Lysophospholipid receptor
• P2Y receptor

References

1. GRCh38: Ensembl release 89: ENSG00000147145 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049929 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR23 G protein-coupled receptor 23".
6. Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor". Biochem. Biophys. Res. Commun. 236 (1): 106–12. doi:10.1006/bbrc.1997.6895. PMID 9223435.
7. O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene. 187 (1): 75–81. doi:10.1016/S0378-1119(96)00722-6. PMID 9073069.
8. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

Further reading

• Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim. Biophys. Acta. 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Noguchi K, Ishii S, Shimizu T (2003). "Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family". J. Biol. Chem. 278 (28): 25600–6. doi:10.1074/jbc.M302648200. PMID 12724320.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.