Free fatty acid receptor

The free fatty acid receptor is a G-protein coupled receptor which binds free fatty acids.[1] There are four variants of the receptor, each encoded by a separate gene (FFAR1, FFAR2, FFAR3, FFAR4). Preliminary findings suggest that FFAR2 and FFAR3 may interact to form a FFAR2-FFAR3 receptor heteromer. [2]

free fatty acid receptor 1
Identifiers
Symbol	FFAR1, FFA1R
Alt. symbols	GPR40
NCBI gene	2864
HGNC	4498
OMIM	603820
RefSeq	NM_005303
UniProt	O14842
Other data
Locus	Chr. 19 q13.1

free fatty acid receptor 2
Identifiers
Symbol	FFAR2
Alt. symbols	GPR43, FFA2R
NCBI gene	2867
HGNC	4501
OMIM	603823
RefSeq	NM_005306
UniProt	O15552
Other data
Locus	Chr. 19 q13.1

free fatty acid receptor 3
Identifiers
Symbol	FFAR3
Alt. symbols	GPR41, FFA3R
NCBI gene	2865
HGNC	4499
OMIM	603821
RefSeq	NM_005304
UniProt	O14843
Other data
Locus	Chr. 19 q13.1

G protein-coupled receptor 42
Identifiers
Symbol	GPR42
Alt. symbols	GPR41L, FFAR1L
NCBI gene	2866
HGNC	4500
OMIM	603822
RefSeq	NM_005305
UniProt	O15529
Other data
Locus	Chr. 19 q31.1

References

1. Covington DK, Briscoe CA, Brown AJ, Jayawickreme CK (2006). "The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing". Biochem. Soc. Trans. 34 (Pt 5): 770–3. doi:10.1042/BST0340770. PMID 17052194.
2. Ang, Zhiwei; Xiong, Ding; Wu, Min; Ding, Jeak Ling (2017-09-07). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". The FASEB Journal. 32: –201700252RR. doi:10.1096/fj.201700252RR. ISSN 0892-6638. PMC 5731126. PMID 28883043. Retrieved 2017-09-10.

External links

• "Free Fatty Acid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• FFAR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• G-protein+coupled+receptor+43,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FFAR3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)