Tachykinin receptor
There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).
| Tachykinin receptor | |
|---|---|
| Identifiers | |
| Symbol | ? |
| InterPro | IPR001681 |
| tachykinin receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | TACR1 |
| Alt. symbols | TAC1R |
| NCBI gene | 6869 |
| HGNC | 11526 |
| OMIM | 162323 |
| RefSeq | NM_001058 |
| UniProt | P25103 |
| Other data | |
| Locus | Chr. 2 p13.1-p12 |
| tachykinin receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | TACR2 |
| Alt. symbols | TAC2R, NKNAR |
| NCBI gene | 6865 |
| HGNC | 11527 |
| OMIM | 162321 |
| RefSeq | NM_001057 |
| UniProt | P21452 |
| Other data | |
| Locus | Chr. 10 q11-q21 |
| tachykinin receptor 3 | |
|---|---|
| Identifiers | |
| Symbol | TACR3 |
| NCBI gene | 6870 |
| HGNC | 11528 |
| OMIM | 162332 |
| RefSeq | NM_001059 |
| UniProt | P29371 |
| Other data | |
| Locus | Chr. 4 q25 |
Inhibitors of NK-1, known as NK-1 receptor antagonists, can be used as antiemetic agents, such as the drug aprepitant.[1]
Binding
The genes and receptor ligands are as follows:[2]
| Receptor | Gene | Preferred ligand |
| NK1 | TACR1 | substance P |
| NK2 | TACR2 | neurokinin A |
| NK3 | TACR3 | neurokinin B |
(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)
gollark: Good suggestion.
gollark: It's probably a weird horrific mess.
gollark: ```1. I need a banking system!while true do 2. Nobody is giving me full code samples! The documentation is too hard! 3. Krist is too hard to use! I'll make my own, that should be simpler. 4. Nobody is giving me full code samples for this *harder* project! 5. Hmm, they're telling me to use krist, let's try that again.end[between all steps] STOP MOCKING ME!```
gollark: We're at I think stage 2 again.
gollark: "code samples"Wow, my prediction was correct!
See also
- Substance P
- G protein coupled receptors
References
- "Aprepitant". NICE. Retrieved 2020-05-10.
- Maggi CA (September 1995). "The mammalian tachykinin receptors". General Pharmacology. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.
External links
- "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Tachykinin+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
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