GPR61

Probable G-protein coupled receptor 61 is a protein that in humans is encoded by the GPR61 gene.[5][6][7]

GPR61
Identifiers
Aliases	GPR61, BALGR, GPCR3, G protein-coupled receptor 61
External IDs	OMIM: 606916 MGI: 2441719 HomoloGene: 12910 GeneCards: GPR61
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 109,539,872 bp[1] End 109,548,406 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.3 Start 108,148,321 bp[2] End 108,154,882 bp[2]
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • GO:0001948 protein binding • arrestin family protein binding Cellular component • integral component of membrane • receptor complex • membrane • cell membrane • endosome • endosome membrane Biological process • signal transduction • G-protein coupled receptor signaling pathway • positive regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83873	229714
Ensembl	ENSG00000156097	ENSMUSG00000046793
UniProt	Q9BZJ8	Q8C010
RefSeq (mRNA)	NM_031936	NM_175470 NM_001305461
RefSeq (protein)	NP_114142	NP_001292390
Location (UCSC)	Chr 1: 109.54 – 109.55 Mb	Chr 3: 108.15 – 108.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000156097 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046793 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367.
6. Cikos S, Gregor P, Koppel J (Nov 2001). "Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain". Biochim Biophys Acta. 1521 (1–3): 66–72. doi:10.1016/s0167-4781(01)00289-5. PMID 11690637.
7. "Entrez Gene: GPR61 G protein-coupled receptor 61".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Conner AC, Hay DL, Simms J, et al. (2005). "A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors". Mol. Pharmacol. 67 (1): 20–31. doi:10.1124/mol.67.1.20. PMID 15615699.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.

See also

• GPR61+receptor,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.