GPR152

Probable G-protein coupled receptor 152 is a protein that in humans is encoded by the GPR152 gene.[4][5]

GPR152
Identifiers
AliasesGPR152, PGR5, G protein-coupled receptor 152
External IDsMGI: 2685519 HomoloGene: 35474 GeneCards: GPR152
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.2Start67,451,301 bp[1]
End67,452,729 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

390212

269053

Ensembl

ENSG00000175514

n/a

UniProt

Q8TDT2

Q8BXS7

RefSeq (mRNA)

NM_206997

NM_206973

RefSeq (protein)

NP_996880

NP_996856

Location (UCSC)Chr 11: 67.45 – 67.45 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of GPR152 function. A conditional knockout mouse line called Gpr152tm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletion.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12]

gollark: Interesting.
gollark: tio!debug
gollark: ```c#include <stdio.h>#include <stdio.h>#include <stdlib.h>#include <limits.h>#include <string.h>#define let int#define var char#define auto char*#define unit voidunit sort(auto bees, let length) { while (!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!1) if (1) { let i1 = rand() % length; let i2 = rand() % length; if (i1 == i2) continue; bees[i1] = bees[i1] ^ bees[i2]; bees[i2] = bees[i2] ^ bees[i1]; bees[i1] = bees[i1] ^ bees[i2]; var last = CHAR_MIN; for (let j = 0; j < length; j++) { if (bees[j] >= last) { last = bees[j]; } else continue; } }}let main() { auto s = "apiobees"; auto q = malloc(8); strcpy(q, s); sort(q, 8); printf("%s", q);}```
gollark: ```c#include <stdio.h>#include <stdio.h>#include <stdlib.h>#include <limits.h>#include <string.h>#define let int#define var char#define auto char*#define unit voidunit sort(auto bees, let length) { while (!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!1) if (1) { let i1 = rand() % length; let i2 = rand() % length; if (i1 == i2) continue; bees[i1] = bees[i1] ^ bees[i2]; bees[i2] = bees[i2] ^ bees[i1]; bees[i1] = bees[i1] ^ bees[i2]; var last = CHAR_MIN; for (let j = 0; j < length; j++) { if (bees[j] >= last) { last = bees[j]; } else continue; } }}let main() { auto s = "apiobees"; auto q = malloc(8); strcpy(q, s); printf("%s", q);}```
gollark: tio!debug

References
  1. GRCh38: Ensembl release 89: ENSG00000175514 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
  5. "Entrez Gene: GPR152 G protein-coupled receptor 152".
  6. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  7. "International Mouse Phenotyping Consortium".
  8. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  11. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  12. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading
  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (Jun 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
  • Gloriam DE, Schiöth HB, Fredriksson R (Apr 2005). "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochimica et Biophysica Acta (BBA) - General Subjects. 1722 (3): 235–46. doi:10.1016/j.bbagen.2004.12.001. PMID 15777626.
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