Somatostatin receptor 5

Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene.[5]

SSTR5
Identifiers
Aliases	SSTR5, SS-5-R, Somatostatin receptor 5
External IDs	MGI: 894282 HomoloGene: 20287 GeneCards: SSTR5
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,078,781 bp[1] End 1,080,142 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 12.62 cM Start 25,489,875 bp[2] End 25,497,288 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • neuropeptide binding • G-protein coupled receptor activity • signal transducer activity • somatostatin receptor activity • peptide binding Cellular component • integral component of membrane • neuron projection • cell membrane • integral component of plasma membrane • membrane Biological process • positive regulation of cytokinesis • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • glucose homeostasis • signal transduction • negative regulation of cell proliferation • regulation of insulin secretion • somatostatin signaling pathway • chemical synaptic transmission • cellular response to glucocorticoid stimulus • neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6755	20609
Ensembl	ENSG00000162009	ENSMUSG00000050824
UniProt	P35346	O08858
RefSeq (mRNA)	NM_001053 NM_001172560 NM_001172572 NM_001172573	NM_001191008 NM_011425
RefSeq (protein)	NP_001044 NP_001166031	NP_001177937 NP_035555
Location (UCSC)	Chr 16: 1.08 – 1.08 Mb	Chr 17: 25.49 – 25.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR5 is a member of the superfamily of receptors having seven transmembrane segments.[6]

See also

• Somatostatin receptor

References

1. GRCh38: Ensembl release 89: ENSG00000162009 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050824 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takeda J, Fernald AA, Yamagata K, Le Beau MM, Bell GI (Aug 1995). "Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization". Genomics. 26 (3): 638–9. doi:10.1016/0888-7543(95)80195-R. PMID 7607700.
6. "Entrez Gene: SSTR5 somatostatin receptor 5".

Further reading

• Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068.
• Montminy MR, Goodman RH, Horovitch SJ, Habener JF (1984). "Primary structure of the gene encoding rat preprosomatostatin". Proc. Natl. Acad. Sci. U.S.A. 81 (11): 3337–40. doi:10.1073/pnas.81.11.3337. PMC 345502. PMID 6145156.
• Panetta R, Greenwood MT, Warszynska A, et al. (1994). "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28". Mol. Pharmacol. 45 (3): 417–27. PMID 7908405.
• O'Carroll AM, Raynor K, Lolait SJ, Reisine T (1994). "Characterization of cloned human somatostatin receptor SSTR5". Mol. Pharmacol. 46 (2): 291–8. PMID 8078491.
• Yamada Y, Kagimoto S, Kubota A, et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochem. Biophys. Res. Commun. 195 (2): 844–52. doi:10.1006/bbrc.1993.2122. PMID 8373420.
• Yamada Y, Stoffel M, Espinosa R, et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.
• Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
• Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". J. Clin. Endocrinol. Metab. 82 (6): 1857–62. doi:10.1210/jc.82.6.1857. PMID 9177396.
• de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.
• Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525.
• Hukovic N, Panetta R, Kumar U, et al. (1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization". J. Biol. Chem. 273 (33): 21416–22. doi:10.1074/jbc.273.33.21416. PMID 9694905.
• Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Mol. Endocrinol. 13 (1): 82–90. doi:10.1210/me.13.1.82. PMID 9892014.
• Kumar U, Sasi R, Suresh S, et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes. 48 (1): 77–85. doi:10.2337/diabetes.48.1.77. PMID 9892225.
• Rocheville M, Lange DC, Kumar U, et al. (2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers". J. Biol. Chem. 275 (11): 7862–9. doi:10.1074/jbc.275.11.7862. PMID 10713101.
• Rocheville M, Lange DC, Kumar U, et al. (2000). "Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity". Science. 288 (5463): 154–7. doi:10.1126/science.288.5463.154. PMID 10753124.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Ballarè E, Persani L, Lania AG, et al. (2001). "Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment". J. Clin. Endocrinol. Metab. 86 (8): 3809–14. doi:10.1210/jc.86.8.3809. PMID 11502816.
• Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.
• Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920.

External links

• "Somatostatin Receptors: sst₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• somatostatin+receptor+5 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.