S1PR4
Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.[5]
Function
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.[5]
gollark: > If you dont want to risk getting infected stay home. If you are okay with the risk then go outThat's not really practical because, as I said, you need food and stuff.
gollark: > youll get into contact with the same number of people at the store regardless of whos out doing something elseBut a different number of them will have COVID-19 and might be able to infect you.
gollark: I guess if you could hibernate somehow...
gollark: Sadly, humans just don't have the surface area.
gollark: And you are less likely to be infected there if you have fewer people going out for nonessential reasons.
See also
References
- GRCh38: Ensembl release 89: ENSG00000125910 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000044199 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: S1PR4 Sphingosine-1-phosphate receptor 4".
Further reading
- Gräler MH, Bernhardt G, Lipp M (1998). "EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue". Genomics. 53 (2): 164–9. doi:10.1006/geno.1998.5491. PMID 9790765.
- Yamazaki Y, Kon J, Sato K, et al. (2000). "Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway". Biochem. Biophys. Res. Commun. 268 (2): 583–9. doi:10.1006/bbrc.2000.2162. PMID 10679247.
- Van Brocklyn JR, Gräler MH, Bernhardt G, et al. (2000). "Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6". Blood. 95 (8): 2624–9. PMID 10753843.
- Idzko M, Panther E, Corinti S, et al. (2002). "Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses". FASEB J. 16 (6): 625–7. doi:10.1096/fj.01-0625fje. PMID 11919175.
- Kveberg L, Bryceson Y, Inngjerdingen M, et al. (2002). "Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases". Eur. J. Immunol. 32 (7): 1856–64. doi:10.1002/1521-4141(200207)32:7<1856::AID-IMMU1856>3.0.CO;2-B. PMID 12115604.
- Candelore MR, Wright MJ, Tota LM, et al. (2002). "Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor". Biochem. Biophys. Res. Commun. 297 (3): 600–6. doi:10.1016/S0006-291X(02)02237-4. PMID 12270137.
- Contos JJ, Ye X, Sah VP, Chun J (2002). "Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene". FEBS Lett. 531 (1): 99–102. doi:10.1016/S0014-5793(02)03409-9. PMID 12401211.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Vogler R, Sauer B, Kim DS, et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". J. Invest. Dermatol. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
- Gräler MH, Grosse R, Kusch A, et al. (2003). "The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13". J. Cell. Biochem. 89 (3): 507–19. doi:10.1002/jcb.10537. PMID 12761884.
- Kyi CS, Key SJ, Lloyd TW (2003). "Use of a nasogastric catheter to prevent soft tissue entanglement of the externally ported distractor arm". International Journal of Oral and Maxillofacial Surgery. 32 (3): 337–8. doi:10.1054/ijom.2003.0364. PMID 12767884.
- Holdsworth G, Osborne DA, Pham TT, et al. (2005). "A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor". BMC Biochem. 5: 12. doi:10.1186/1471-2091-5-12. PMC 514652. PMID 15298705.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
External links
- "Lysophospholipid Receptors: S1P4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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