GPR68

Ovarian cancer G-protein coupled receptor 1 is a protein that in humans is encoded by the GPR68 gene.[5][6]

GPR68
Identifiers
Aliases	GPR68, GPR12A, OGR1, G protein-coupled receptor 68, AI2A6
External IDs	OMIM: 601404 MGI: 2441763 HomoloGene: 2603 GeneCards: GPR68
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.11 Start 91,232,532 bp[1] End 91,253,925 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 100,876,682 bp[2] End 100,908,198 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane Biological process • G-protein coupled receptor signaling pathway • negative regulation of monocyte differentiation • positive regulation of insulin secretion involved in cellular response to glucose stimulus • cellular response to pH • inflammatory response • positive regulation of osteoclast development • signal transduction • positive regulation of insulin secretion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8111	238377
Ensembl	ENSG00000119714	ENSMUSG00000047415
UniProt	Q15743	Q8BFQ3
RefSeq (mRNA)	NM_001177676 NM_003485 NM_001348437	NM_001177673 NM_001177674 NM_175493
RefSeq (protein)	NP_001171147 NP_003476 NP_001335366	NP_001171144 NP_001171145 NP_780702
Location (UCSC)	Chr 14: 91.23 – 91.25 Mb	Chr 12: 100.88 – 100.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Proton-sensing G protein-coupled receptors

References

1. GRCh38: Ensembl release 89: ENSG00000119714 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047415 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu Y, Casey G (Sep 1996). "Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14". Genomics. 35 (2): 397–402. doi:10.1006/geno.1996.0377. PMID 8661159.
6. "Entrez Gene: GPR68 G protein-coupled receptor 68".

Further reading

• Xu Y (2002). "Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction". Biochim. Biophys. Acta. 1582 (1–3): 81–8. doi:10.1016/S1388-1981(02)00140-3. PMID 12069813.
• An S, Tsai C, Goetzl EJ (1996). "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue". FEBS Lett. 375 (1–2): 121–4. doi:10.1016/0014-5793(95)01196-L. PMID 7498459.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ludwig MG, Vanek M, Guerini D, et al. (2003). "Proton-sensing G-protein-coupled receptors". Nature. 425 (6953): 93–8. doi:10.1038/nature01905. PMID 12955148.
• Bektas M, Barak LS, Jolly PS, et al. (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner". Biochemistry. 42 (42): 12181–91. doi:10.1021/bi035051y. PMID 14567679.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Radu CG, Nijagal A, McLaughlin J, et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. doi:10.1073/pnas.0409415102. PMC 545089. PMID 15665078.
• Tomura H, Wang JQ, Komachi M, et al. (2005). "Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells". J. Biol. Chem. 280 (41): 34458–64. doi:10.1074/jbc.M505287200. PMID 16087674.
• Singh LS, Berk M, Oates R, et al. (2007). "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer". J. Natl. Cancer Inst. 99 (17): 1313–27. doi:10.1093/jnci/djm107. PMID 17728215.