Neuropeptide B/W receptor
The neuropeptide B/W receptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the neuropeptides B and W.[1] These receptors are predominantly expressed in the CNS and have a number of functions including regulation of the secretion of cortisol.[2][3]
| neuropeptides B/W receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | NPBWR1 |
| Alt. symbols | GPR7 |
| NCBI gene | 2831 |
| HGNC | 4522 |
| OMIM | 600730 |
| RefSeq | NM_005285 |
| UniProt | P48145 |
| Other data | |
| Locus | Chr. 8 p22-q21.13 |
| neuropeptides B/W receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | NPBWR2 |
| Alt. symbols | GPR8 |
| NCBI gene | 2832 |
| HGNC | 4530 |
| OMIM | 600731 |
| RefSeq | NM_005286 |
| UniProt | P48146 |
| Other data | |
| Locus | Chr. 20 q13.3 |
References
- Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. doi:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
- Mazzocchi G, Rebuffat P, Ziolkowska A, Rossi GP, Malendowicz LK, Nussdorfer GG (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.
- Singh G, Davenport AP (2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". Br. J. Pharmacol. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
External links
- "Neuropeptide W/Neuropeptide B Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- NPBWR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- GPR8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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