Class C GPCR

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

7 transmembrane receptor (metabotropic glutamate family)
Identifiers
Symbol	7tm_3
Pfam	PF00003
InterPro	IPR000337
PROSITE	PDOC00754
TCDB	9.A.14
OPM superfamily	6
OPM protein	4or2
CDD	cd13953
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

The class C G-protein-coupled receptors (InterPro: IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (InterPro: IPR000162) and several additional receptors.[1]

Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length.[1] This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors.

Subfamilies

extracellular calcium-sensing receptor-related InterPro: IPR000068
- Calcium-sensing receptor (CASR)
- GPRC6A (GPRC6A)

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Bräuner-Osborne H, Wellendorph P, Jensen AA (2007). "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors". Curr Drug Targets. 8 (1): 169–84. doi:10.2174/138945007779315614. PMID 17266540.

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