Propamocarb

Propamocarb
Names
	IUPAC name Propyl [3-(dimethylamino)propyl]carbamate
Identifiers
CAS Number	24579-73-5 ; 25606-41-1 (HCl) ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:82033;
ChEMBL	ChEMBL1907431;
ChemSpider	30114;
ECHA InfoCard	100.109.082
PubChem CID	32490;
UNII	8HLL7N9UWO ; V39TC0925S (HCl) ;
CompTox Dashboard (EPA)	DTXSID1040295 ;
	InChI InChI=1S/C9H20N2O2/c1-4-8-13-9(12)10-6-5-7-11(2)3/h4-8H2,1-3H3,(H,10,12) Key: WZZLDXDUQPOXNW-UHFFFAOYSA-N; InChI=1/C9H20N2O2/c1-4-8-13-9(12)10-6-5-7-11(2)3/h4-8H2,1-3H3,(H,10,12) Key: WZZLDXDUQPOXNW-UHFFFAOYAA;
	SMILES O=C(OCCC)NCCCN(C)C;
Properties
Chemical formula	C9H20N2O2
Molar mass	188.271 g·mol−1
Density	0.957 g/cm3
Hazards
Main hazards	Xn
Flash point	109.1 °C (228.4 °F; 382.2 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Propamocarb is a systemic fungicide used for control of soil, root and leaf disease caused by oomycetes. It is used by watering or spraying. Propamocarb is absorbed and distributed through the plant's tissue.

Use

Propamocarb has fungicidal activity only against oomycetes.

Safety

Propamocarb has low general toxicity, and almost no teratogenicity or neurotoxicity for mammals. It is not a carcinogen nor mutagen.[1][2] Propamocarb is not susceptible to formation of resistant diseases. It is fully metabolized by plants and aquatic bacteria in a few weeks, so it is not a major ecological threat. It carries the risk of skin sensitization. Oral LD₅₀ is 2900 mg/kg for male rats and 2000 mg/kg for female rats.[2]

In one study conducted on tobacco, cucumber and spinach, using propamocarb synthesized out of carbon C¹⁴ radionuclide, researchers stated that propamocarb is decomposed down to carbon dioxide and then incorporated into the plant's natural compounds,[2] such as amino acids.

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References

Propamocarb Hydrochloride, United States Environmental Protection Agency
Propamocarb Hydrochloride; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food, Federal Register, Vol. 69, No. 47, March 10, 2004

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[epa0-1] Propamocarb Hydrochloride, United States Environmental Protection Agency

[gpo0-2] Propamocarb Hydrochloride; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food, Federal Register, Vol. 69, No. 47, March 10, 2004