Prokineticin receptor
The prokineticin receptor is a G protein-coupled receptor which binds the peptide hormone prokineticin. There are two variants each encoded by a different gene (PROKR1, PROKR2).[1] These receptors mediate gastrointestinal smooth muscle contraction and angiogenesis.
| prokineticin receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | PROKR1 |
| Alt. symbols | GPR73 |
| NCBI gene | 10887 |
| HGNC | 4524 |
| OMIM | 607122 |
| RefSeq | NM_138964 |
| UniProt | Q8TCW9 |
| Other data | |
| Locus | Chr. 2 p14 |
| prokineticin receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | PROKR2 |
| Alt. symbols | GPR73L1 |
| NCBI gene | 128674 |
| HGNC | 15836 |
| OMIM | 607123 |
| RefSeq | NM_144773 |
| UniProt | Q8NFJ6 |
| Other data | |
| Locus | Chr. 20 p12.3 |
References
- Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY (2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor". J. Biol. Chem. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876.
External links
- "Prokineticin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- PROKR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- PROKR2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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