Platelet-activating factor receptor

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.[5][6]

PTAFR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B0X
Identifiers
Aliases	PTAFR, PAFR, platelet activating factor receptor
External IDs	OMIM: 173393 MGI: 106066 HomoloGene: 20260 GeneCards: PTAFR
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 28,147,166 bp[1] End 28,193,936 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.3|4 65.56 cM Start 132,564,067 bp[2] End 132,582,683 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • G-protein coupled purinergic nucleotide receptor activity • lipopolysaccharide binding • signal transducer activity • mitogen-activated protein kinase binding • platelet activating factor receptor activity • phospholipid binding • lipopolysaccharide receptor activity • GO:0001948 protein binding Cellular component • integral component of membrane • membrane • integral component of plasma membrane • cell membrane • secretory granule membrane • tertiary granule membrane Biological process • G-protein coupled receptor signaling pathway • positive regulation of leukocyte tethering or rolling • inositol trisphosphate biosynthetic process • positive regulation of voltage-gated chloride channel activity • positive regulation of phospholipase C activity • negative regulation of blood pressure • interferon-gamma-mediated signaling pathway • positive regulation of inositol phosphate biosynthetic process • regulation of transcription from RNA polymerase II promoter • positive regulation of transcytosis • cytokine production • response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine • response to symbiotic bacterium • transcytosis • positive regulation of translation • positive regulation of interleukin-6 biosynthetic process • cellular response to gravity • response to dexamethasone • positive regulation of cellular extravasation • positive regulation of maternal process involved in parturition • chemotaxis • cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine • positive regulation of sensory perception of pain • response to lipopolysaccharide • cellular response to fatty acid • response to organophosphorus • birth • positive regulation of vasoconstriction • immune response • positive regulation of gastro-intestinal system smooth muscle contraction • positive regulation of tumor necrosis factor production • inflammatory response • positive regulation of smooth muscle contraction • positive regulation of neutrophil degranulation • positive regulation of leukocyte cell-cell adhesion • phosphatidylinositol-mediated signaling • lipopolysaccharide-mediated signaling pathway • cellular response to cAMP • signal transduction • positive regulation of smooth muscle cell proliferation • G-protein coupled purinergic nucleotide receptor signaling pathway • neutrophil degranulation • positive regulation of blood vessel diameter • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5724	19204
Ensembl	ENSG00000169403	ENSMUSG00000056529
UniProt	P25105	Q62035
RefSeq (mRNA)	NM_001164723 NM_000952 NM_001164721 NM_001164722	NM_001081211
RefSeq (protein)	NP_000943 NP_001158193 NP_001158194 NP_001158195	NP_001074680
Location (UCSC)	Chr 1: 28.15 – 28.19 Mb	Chr 4: 132.56 – 132.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.[8]

Ligands

Agonists

• Platelet activating factor

Antagonists

• Israpafant (Y-24180)
• WEB 2086

References

1. GRCh38: Ensembl release 89: ENSG00000169403 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056529 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics. 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
6. Ishii S, Nagase T, Shimizu T (2002). "Platelet-activating factor receptor". Prostaglandins Other Lipid Mediat. 68-69: 599–609. doi:10.1016/S0090-6980(02)00058-8. PMID 12432946.
7. "Entrez Gene: PTAFR platelet-activating factor receptor".
8. Correa-Costa M (Apr 2014). "Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis". Lab. Invest. 94 (4): 455–466. doi:10.1038/labinvest.2013.155. PMID 24492283.

Further reading

• Shukla SD (1992). "Platelet-activating factor receptor and signal transduction mechanisms". FASEB J. 6 (6): 2296–301. doi:10.1096/fasebj.6.6.1312046. PMID 1312046.
• Sugimoto T, Tsuchimochi H, McGregor CG, et al. (1993). "Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart". Biochem. Biophys. Res. Commun. 189 (2): 617–24. doi:10.1016/0006-291X(92)92245-S. PMID 1281995.
• Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics. 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
• Kunz D, Gerard NP, Gerard C (1992). "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog". J. Biol. Chem. 267 (13): 9101–6. PMID 1374385.
• Ye RD, Prossnitz ER, Zou AH, Cochrane CG (1991). "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor". Biochem. Biophys. Res. Commun. 180 (1): 105–11. doi:10.1016/S0006-291X(05)81261-6. PMID 1656963.
• Nakamura M, Honda Z, Izumi T, et al. (1991). "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes". J. Biol. Chem. 266 (30): 20400–5. PMID 1657923.
• Haslam RJ, Williams KA, Davidson MM (1986). Receptor-effector coupling in platelets: roles of guanine nucleotides. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 192. pp. 265–80. doi:10.1007/978-1-4615-9442-0_19. ISBN 978-1-4615-9444-4. PMID 3010668.
• Valone FH (1984). "Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine". Immunology. 52 (1): 169–74. PMC 1454573. PMID 6325330.
• Cundell DR, Gerard NP, Gerard C, et al. (1995). "Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor". Nature. 377 (6548): 435–8. doi:10.1038/377435a0. PMID 7566121.
• Izumi T, Kishimoto S, Takano T, et al. (1995). "Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation". Biochem. J. 305. ( Pt 3) (3): 829–35. doi:10.1042/bj3050829. PMC 1136334. PMID 7848283.
• Bito H, Honda Z, Nakamura M, Shimizu T (1994). "Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA". Eur. J. Biochem. 221 (1): 211–8. doi:10.1111/j.1432-1033.1994.tb18731.x. PMID 8168510.
• Chase PB, Halonen M, Regan JW (1993). "Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region". Am. J. Respir. Cell Mol. Biol. 8 (3): 240–4. doi:10.1165/ajrcmb/8.3.240. PMID 8383507.
• Mutoh H, Bito H, Minami M, et al. (1993). "Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor". FEBS Lett. 322 (2): 129–34. doi:10.1016/0014-5793(93)81552-B. PMID 8387031.
• Nakamura M, Honda Z, Matsumoto T, et al. (1993). "Isolation and properties of platelet-activating factor receptor cDNAs". Journal of Lipid Mediators. 6 (1–3): 163–8. PMID 8395240.
• Kishimoto S, Shimadzu W, Izumi T, et al. (1996). "Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils". J. Immunol. 157 (9): 4126–32. PMID 8892648.
• Chase PB, Yang JM, Thompson FH, et al. (1997). "Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35→p34.3 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 72 (2–3): 205–7. doi:10.1159/000134190. PMID 8978777.
• Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J (1997). "Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor". FEBS Lett. 402 (2–3): 203–8. doi:10.1016/S0014-5793(96)01531-1. PMID 9037196.
• Ahmed A, Dearn S, Shams M, et al. (1998). "Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125". FASEB J. 12 (10): 831–43. doi:10.1096/fasebj.12.10.831. PMID 9657523.
• Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209.

External links

• "Platelet-Activating Factor Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• platelet+activating+factor+receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.