Kobophenol A

Kobophenol A is a stilbenoid. It is a tetramer of resveratrol. It can be isolated from Caragana chamlagu,[1] from Caragana sinica[2] and from Carex folliculata seeds.[3]

Kobophenol A

Names
IUPAC name 5-[(2S,3R,4S,5S)-4-[(2S,3S)-3-[(2R,3R)-3-(3,5-dihydroxyphenyl)-6-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuran-4-yl]-6-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuran-4-yl]-2,5-bis(4-hydroxyphenyl)oxolan-3-yl]benzene-1,3-diol
Other names kob A
Identifiers
CAS Number	124027-58-3^N
3D model (JSmol)	Interactive image
ChemSpider	425066^N
PubChem CID	484758
CompTox Dashboard (EPA)	DTXSID00333128
InChI InChI=1S/C56H44O13/c57-33-9-1-27(2-10-33)53-47(31-17-37(61)21-38(62)18-31)49-43(23-41(65)25-45(49)67-53)52-50-44(24-42(66)26-46(50)68-55(52)29-5-13-35(59)14-6-29)51-48(32-19-39(63)22-40(64)20-32)54(28-3-11-34(58)12-4-28)69-56(51)30-7-15-36(60)16-8-30/h1-26,47-48,51-66H/t47-,48+,51-,52+,53+,54-,55-,56-/m1/s1^N Key: RAUCCLKIJHMTND-LUPMIFTGSA-N^N InChI=1/C56H44O13/c57-33-9-1-27(2-10-33)53-47(31-17-37(61)21-38(62)18-31)49-43(23-41(65)25-45(49)67-53)52-50-44(24-42(66)26-46(50)68-55(52)29-5-13-35(59)14-6-29)51-48(32-19-39(63)22-40(64)20-32)54(28-3-11-34(58)12-4-28)69-56(51)30-7-15-36(60)16-8-30/h1-26,47-48,51-66H/t47-,48+,51-,52+,53+,54-,55-,56-/m1/s1 Key: RAUCCLKIJHMTND-LUPMIFTGBD
SMILES Oc1ccc(cc1)[C@@H]4Oc2cc(O)cc(c2[C@H]4c3cc(O)cc(O)c3)[C@H]6c7c(O[C@@H]6c5ccc(O)cc5)cc(O)cc7[C@H]%10[C@H](O[C@H](c8ccc(O)cc8)[C@H]%10c9cc(O)cc(O)c9)c%11ccc(O)cc%11
Properties
Chemical formula	C56H44O13
Molar mass	924.94 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

The molecule shows a 2,3,4,5-tetraaryltetrahydrofuran skeleton.[3]

It has been shown to inhibit acetylcholinesterase.[1]

Acid-catalyzed epimerization of kobophenol A to carasinol B can be performed in vitro.[4]

References

1. (+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase. Sang Hyun Sung, So Young Kang, Ki Yong Lee, Mi Jung Park, Jeong Hun Kim, Jong Hee Park, Young Chul Kim, Jinwoong Kim and Young Choong Kim, Biological & Pharmaceutical Bulletin, Vol. 25, 2002
2. Simultaneous determination of the contents of three stilbene oligomers in Caragana sinica collected in different seasons using an improved HPLC method. Shu Na; Zhou Hong; Hu Changqi, Biological & pharmaceutical bulletin, 2006, vol. 29, no4, pp. 608-612
3. Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds. Li L, Henry GE and Seeram NP, J Agric Food Chem., 26 August 2009, volume 57, issue 16, pages 7282-7287, doi:10.1021/jf901716j
4. Acid-catalyzed Epimerization of Kobophenol A to Carasinol B. Kejun Cheng, Gaolin Liang and Changqi Hu, Molecules 2008, 13(4), 938-942