WAY-213,613

WAY-213,613 is a drug which acts as a reuptake inhibitor for the glutamate transporter subtype EAAT2, selective over other glutamate transporter subtypes and highly selective over metabotropic and ionotropic glutamate receptors.[1] It is used in scientific research into the function of the glutamate transporters.[2]

WAY-213,613
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.212.988
Chemical and physical data
FormulaC16H13BrF2N2O4
Molar mass415.191 g·mol−1
3D model (JSmol)
 NY (what is this?)  (verify)

References

  1. Dunlop J, McIlvain HB, Carrick TA, Jow B, Lu Q, Kowal D, et al. (October 2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2". Molecular Pharmacology. 68 (4): 974–82. doi:10.1124/mol.105.012005. PMID 16014807.
  2. Karatas-Wulf U, Koepsell H, Bergert M, Sönnekes S, Kugler P (July 2009). "Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells". Neuroscience. 161 (3): 794–805. doi:10.1016/j.neuroscience.2009.04.017. PMID 19364521.
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