Phosphatidylinositol 3-kinase-related kinase
Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks).[1]
Members
The human PIKK family includes six members:
| Gene | Protein | Function |
|---|---|---|
| ATM | ataxia-telangiectasia mutated | response to DNA damage |
| ATR | ataxia- and Rad3-related | " |
| PRKDC | DNA-dependent protein kinase catalytic subunit (DNA-PKcs) | " |
| MTOR | mammalian target of rapamycin (mTOR) | nutrient-regulated kinase that controls metabolism and cell growth |
| SMG1 | suppressor of morphogenesis in genitalia | regulates nonsense-mediated mRNA decay |
| TRRAP | transformation/transcription domain-associated protein | transcription factor co-activator |
Structure
PIKKs proteins contain the following four domains:
- N-terminus FRAP-ATM- TRRAP (FAT) domain, Pfam PF02259
- kinase domain (KD; PI3_PI4_kinase),
- PIKK- regulatory domain (PRD), and
- C-terminus FAT-C-terminal (FATC) domain Pfam PF02260
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References
- Lempiäinen H, Halazonetis TD (October 2009). "Emerging common themes in regulation of PIKKs and PI3Ks". EMBO J. 28 (20): 3067–73. doi:10.1038/emboj.2009.281. PMC 2752028. PMID 19779456.
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