DCLK1

Serine/threonine-protein kinase DCLK1 is an enzyme that in humans is encoded by the DCLK1 gene.[5][6][7]

DCLK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MFW, 1MG4, 1UF0
Identifiers
Aliases	DCLK1, CL1, CLICK1, DCAMKL1, DCDC3A, DCLK, doublecortin like kinase 1
External IDs	OMIM: 604742 MGI: 1330861 HomoloGene: 130530 GeneCards: DCLK1
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q13.3 Start 35,768,652 bp[1] End 36,131,306 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 C Start 55,242,364 bp[2] End 55,539,068 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • kinase activity • ATP binding • protein serine/threonine kinase activity Cellular component • integral component of plasma membrane • intracellular • GO:0097483, GO:0097481 postsynaptic density Biological process • cell differentiation • axonogenesis • dendrite morphogenesis • phosphorylation • response to virus • neuron migration • nervous system development • multicellular organism development • endosomal transport • protein phosphorylation • central nervous system development • brain development • axon extension • forebrain development • central nervous system projection neuron axonogenesis • negative regulation of protein localization to nucleus • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • GO:0007243 intracellular signal transduction • neuron projection morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9201	13175
Ensembl	ENSG00000133083	ENSMUSG00000027797
UniProt	O15075	Q9JLM8
RefSeq (mRNA)	NM_001195415 NM_001195416 NM_001195430 NM_004734 NM_001330071 NM_001330072	NM_001111051 NM_001111052 NM_001111053 NM_001195538 NM_001195539 NM_001195540 NM_019978 NM_001357466 NM_001357468 NM_001357469 NM_001357475 NM_001357476
RefSeq (protein)	NP_001182344 NP_001182345 NP_001182359 NP_001317000 NP_001317001 NP_004725	NP_001104521 NP_001104522 NP_001104523 NP_001182467 NP_001182468 NP_001182469 NP_064362 NP_001344395 NP_001344397 NP_001344398 NP_001344404 NP_001344405
Location (UCSC)	Chr 13: 35.77 – 36.13 Mb	Chr 3: 55.24 – 55.54 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

DCLK1 is a marker for tuft cells.

References

1. GRCh38: Ensembl release 89: ENSG00000133083 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027797 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T (Oct 1998). "Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin". J Hum Genet. 43 (3): 169–77. doi:10.1007/s100380050063. PMID 9747029.
6. Sossey-Alaoui K, Srivastava AK (May 1999). "DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)". Genomics. 56 (1): 121–6. doi:10.1006/geno.1998.5718. PMID 10036192.
7. "Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1".

Further reading

• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Matsumoto N, Pilz DT, Ledbetter DH (1999). "Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS)". Genomics. 56 (2): 179–83. doi:10.1006/geno.1998.5673. PMID 10051403.
• Lin PT, Gleeson JG, Corbo JC, et al. (2001). "DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization". J. Neurosci. 20 (24): 9152–61. doi:10.1523/JNEUROSCI.20-24-09152.2000. PMID 11124993.
• Burgess HA, Reiner O (2002). "Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities". J. Biol. Chem. 277 (20): 17696–705. doi:10.1074/jbc.M111981200. PMID 11884394.
• Kim MH, Derewenda U, Devedjiev Y, et al. (2003). "Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase". Acta Crystallogr. D. 59 (Pt 3): 502–5. doi:10.1107/S0907444903000027. PMID 12595708.
• Kim MH, Cierpicki T, Derewenda U, et al. (2003). "The DCX-domain tandems of doublecortin and doublecortin-like kinase". Nat. Struct. Biol. 10 (5): 324–33. doi:10.1038/nsb918. PMID 12692530.
• Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. PMID 14613930.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.

External links

• Overview of all the structural information available in the PDB for UniProt: O15075 (Serine/threonine-protein kinase DCLK1) at the PDBe-KB.