MKNK2

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.[5][6]

MKNK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AC3, 2AC5
Identifiers
Aliases	MKNK2, GPRK7, MNK2, MAP kinase interacting serine/threonine kinase 2, MAPK interacting serine/threonine kinase 2
External IDs	OMIM: 605069 MGI: 894279 HomoloGene: 49674 GeneCards: MKNK2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,037,465 bp[1] End 2,051,244 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,665,327 bp[2] End 80,678,112 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • calcium-dependent protein serine/threonine kinase activity • metal ion binding • calmodulin binding • kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • calmodulin-dependent protein kinase activity • ATP binding Cellular component • cytoplasm • PML body • nuclear body • cell nucleus • nucleoplasm Biological process • GO:0007243 intracellular signal transduction • phosphorylation • protein phosphorylation • cell surface receptor signaling pathway • cellular response to arsenic-containing substance • peptidyl-serine phosphorylation • extrinsic apoptotic signaling pathway in absence of ligand • autophosphorylation • regulation of translation • apoptotic process • haematopoiesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2872	17347
Ensembl	ENSG00000099875	ENSMUSG00000020190
UniProt	Q9HBH9	Q8CDB0
RefSeq (mRNA)	NM_199054 NM_017572	NM_021462
RefSeq (protein)	NP_060042 NP_951009	NP_067437
Location (UCSC)	Chr 19: 2.04 – 2.05 Mb	Chr 10: 80.67 – 80.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MKNK2 has been shown to interact with MAPK1[7][8] and Eukaryotic translation initiation factor 4 gamma.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000099875 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020190 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP (Oct 2000). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta". Genomics. 69 (1): 63–71. doi:10.1006/geno.2000.6299. PMID 11013076.
6. "Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2".
7. Scheper, Gert C; Parra Josep L; Wilson Mary; Van Kollenburg Barbara; Vertegaal Alfred C O; Han Ze-Guang; Proud Christopher G (Aug 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Mol. Cell. Biol. United States. 23 (16): 5692–705. doi:10.1128/MCB.23.16.5692-5705.2003. ISSN 0270-7306. PMC 166352. PMID 12897141.
8. Waskiewicz, A J; Flynn A; Proud C G; Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. ENGLAND. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMC 1169794. PMID 9155017.

Further reading

• Haribabu B, Snyderman R (1993). "Identification of additional members of human G-protein-coupled receptor kinase multigene family". Proc. Natl. Acad. Sci. U.S.A. 90 (20): 9398–402. Bibcode:1993PNAS...90.9398H. doi:10.1073/pnas.90.20.9398. PMC 47575. PMID 8415712.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. PMC 1169794. PMID 9155017.
• Scheper GC, Morrice NA, Kleijn M, Proud CG (2001). "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells". Mol. Cell. Biol. 21 (3): 743–54. doi:10.1128/MCB.21.3.743-754.2001. PMC 86666. PMID 11154262.
• Knauf U, Tschopp C, Gram H (2001). "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2". Mol. Cell. Biol. 21 (16): 5500–11. doi:10.1128/MCB.21.16.5500-5511.2001. PMC 87272. PMID 11463832.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scheper GC, Parra JL, Wilson M, et al. (2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Mol. Cell. Biol. 23 (16): 5692–705. doi:10.1128/MCB.23.16.5692-5705.2003. PMC 166352. PMID 12897141.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yoshizuka N, Yoshizuka-Chadani Y, Krishnan V, Zeichner SL (2005). "Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway". J. Virol. 79 (17): 11366–81. doi:10.1128/JVI.79.17.11366-11381.2005. PMC 1193619. PMID 16103188.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Jauch R, Jäkel S, Netter C, et al. (2006). "Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site". Structure. 13 (10): 1559–68. doi:10.1016/j.str.2005.07.013. hdl:11858/00-001M-0000-0010-9408-D. PMID 16216586.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wang P, Wang X, Wang F, et al. (2006). "Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex". Science in China Series C: Life Sciences. 49 (3): 265–73. doi:10.1007/s11427-006-0265-5. PMID 16856496.