Tropomyosin kinase
In enzymology, a tropomyosin kinase (EC 2.7.11.28) is an enzyme that catalyzes the chemical reaction
- ATP + tropomyosin ADP + O-phosphotropomyosin
| tropomyosin kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.11.28 | ||||||||
| CAS number | 90804-56-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are ATP and tropomyosin, whereas its two products are ADP and O-phosphotropomyosin.
This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:tropomyosin O-phosphotransferase. Other names in common use include tropomyosin kinase (phosphorylating), and STK.
References
- deBelle I, Mak AS (1987). "Isolation and characterization of tropomyosin kinase from chicken embryo". Biochim. Biophys. Acta. 925 (1): 17–26. doi:10.1016/0304-4165(87)90143-7. PMID 3593768.
- Montgomery K, Mak AS (1984). "In vitro phosphorylation of tropomyosin by a kinase from chicken embryo". J. Biol. Chem. 259 (9): 5555–60. PMID 6325440.
- Watson MH, Taneja AK, Hodges RS, Mak AS (1988). "Phosphorylation of alpha alpha- and beta beta-tropomyosin and synthetic peptide analogues". Biochemistry. 27 (12): 4506–12. doi:10.1021/bi00412a043. PMID 3166994.
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