GNG7

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 is a protein that in humans is encoded by the GNG7 gene.[5][6]

GNG7
Identifiers
Aliases	GNG7, G protein subunit gamma 7
External IDs	OMIM: 604430 MGI: 95787 HomoloGene: 31293 GeneCards: GNG7
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,511,219 bp[1] End 2,702,694 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 80,948,624 bp[2] End 81,014,945 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • GTPase activity • G-protein beta-subunit binding Cellular component • heterotrimeric G-protein complex • cell membrane • extracellular exosome • membrane • G-protein beta/gamma-subunit complex Biological process • G-protein coupled receptor signaling pathway • cellular response to glucagon stimulus • regulation of G-protein coupled receptor protein signaling pathway • signal transduction • behavioral fear response • receptor guanylyl cyclase signaling pathway • locomotory behavior • regulation of adenylate cyclase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2788	14708
Ensembl	ENSG00000176533	ENSMUSG00000048240
UniProt	O60262	Q61016
RefSeq (mRNA)	NM_052847	NM_001038655 NM_010319
RefSeq (protein)	NP_443079	NP_001033744 NP_034449
Location (UCSC)	Chr 19: 2.51 – 2.7 Mb	Chr 10: 80.95 – 81.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GNG7 has been shown to interact with GNB5.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000176533 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048240 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shibata K, Mori M, Tanaka S, Kitano S, Akiyoshi T (Jun 1998). "Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer". Biochem. Biophys. Res. Commun. 246 (1): 205–9. doi:10.1006/bbrc.1998.8581. PMID 9600093.
6. "Entrez Gene: GNG7 guanine nucleotide binding protein (G protein), gamma 7".
7. Yan K, Kalyanaraman V, Gautam N (Mar 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.

Further reading

• Ueda N, Iñiguez-Lluhi JA, Lee E, Smrcka AV, Robishaw JD, Gilman AG (1994). "G protein beta gamma subunits. Simplified purification and properties of novel isoforms". J. Biol. Chem. 269 (6): 4388–95. PMID 8308009.
• Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.