GNG13

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 is a protein that in humans is encoded by the GNG13 gene.[5][6]

GNG13
Identifiers
Aliases	GNG13, G(gamma)13, h2-35, G protein subunit gamma 13
External IDs	OMIM: 607298 MGI: 1925616 HomoloGene: 81890 GeneCards: GNG13
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 798,041 bp[1] End 800,734 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 25,717,171 bp[2] End 25,719,406 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein beta-subunit binding • signal transducer activity • GTPase activity Cellular component • cell membrane • dendrite • membrane • heterotrimeric G-protein complex Biological process • phospholipase C-activating G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway • sensory perception of taste • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51764	64337
Ensembl	ENSG00000127588	ENSMUSG00000025739
UniProt	Q9P2W3	Q9JMF3
RefSeq (mRNA)	NM_016541	NM_022422 NM_001357782
RefSeq (protein)	NP_057625	NP_071867 NP_001344711
Location (UCSC)	Chr 16: 0.8 – 0.8 Mb	Chr 17: 25.72 – 25.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GNG13 has been shown to interact with GNB5.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000127588 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025739 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Huang L, Shanker YG, Dubauskaite J, Zheng JZ, Yan W, Rosenzweig S, Spielman AI, Max M, Margolskee RF (Jan 2000). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium". Nat Neurosci. 2 (12): 1055–62. doi:10.1038/15981. PMID 10570481.
6. "Entrez Gene: GNG13 guanine nucleotide binding protein (G protein), gamma 13".
7. Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (Dec 2001). "G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)". J. Biol. Chem. 276 (52): 49267–74. doi:10.1074/jbc.M106565200. PMID 11675383.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (2002). "G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)". J. Biol. Chem. 276 (52): 49267–74. doi:10.1074/jbc.M106565200. PMID 11675383.
• Huang L, Max M, Margolskee RF, Su H, Masland RH, Euler T (2003). "G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells". J. Comp. Neurol. 455 (1): 1–10. doi:10.1002/cne.10396. PMID 12454992.
• Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
• Kato C, Mizutani T, Tamaki H, Kumagai H, Kamiya T, Hirobe A, Fujisawa Y, Kato H, Iwasaki Y (2004). "Characterization of heterotrimeric G protein complexes in rice plasma membrane". Plant J. 38 (2): 320–31. doi:10.1111/j.1365-313X.2004.02046.x. PMID 15078334.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Li Z, Benard O, Margolskee RF (2006). "Ggamma13 interacts with PDZ domain-containing proteins". J. Biol. Chem. 281 (16): 11066–73. doi:10.1074/jbc.M600113200. PMID 16473877.