GNG4

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 is a protein that in humans is encoded by the GNG4 gene.[5][6]

GNG4
Identifiers
Aliases	GNG4, G protein subunit gamma 4
External IDs	OMIM: 604388 MGI: 102703 HomoloGene: 3299 GeneCards: GNG4
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.3 Start 235,547,685 bp[1] End 235,650,754 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A1|13 5.29 cM Start 13,784,059 bp[2] End 13,827,896 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • signal transducer activity • GTPase activity • G-protein beta-subunit binding Cellular component • cell membrane • extracellular exosome • membrane • heterotrimeric G-protein complex • G-protein beta/gamma-subunit complex Biological process • G-protein coupled receptor signaling pathway • cellular response to glucagon stimulus • negative regulation of cell growth • regulation of G-protein coupled receptor protein signaling pathway • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2786	14706
Ensembl	ENSG00000168243 ENSG00000282972	ENSMUSG00000021303
UniProt	P50150	P50153
RefSeq (mRNA)	NM_001098721 NM_001098722 NM_004485	NM_010317 NM_001302997
RefSeq (protein)	NP_001092191 NP_001092192 NP_004476	NP_001289926 NP_034447
Location (UCSC)	Chr 1: 235.55 – 235.65 Mb	Chr 13: 13.78 – 13.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GNG4 has been shown to sometimes interact with GNB1.[5]{[7]

References

1. ENSG00000282972 GRCh38: Ensembl release 89: ENSG00000168243, ENSG00000282972 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021303 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ray K, Kunsch C, Bonner LM, Robishaw JD (Oct 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765–71. doi:10.1074/jbc.270.37.21765. PMID 7665596.
6. "Entrez Gene: GNG4 guanine nucleotide binding protein (G protein), gamma 4".
7. Yan K, Kalyanaraman V, Gautam N (Mar 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.

Further reading

• Downes GB, Gautam N (1999). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
• Pumiglia KM, LeVine H, Haske T, Habib T, Jove R, Decker SJ (1995). "A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase". J. Biol. Chem. 270 (24): 14251–4. doi:10.1074/jbc.270.24.14251. PMID 7782277.
• Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
• Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.