GNG12

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 is a protein that in humans is encoded by the GNG12 gene.[5][6]

GNG12
Identifiers
Aliases	GNG12, G protein subunit gamma 12
External IDs	OMIM: 615405 MGI: 1336171 HomoloGene: 32427 GeneCards: GNG12
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 67,701,475 bp[1] End 67,833,467 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C1|6 30.68 cM Start 66,896,397 bp[2] End 67,021,350 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphate ion binding • PDZ domain binding • GO:0001948 protein binding • signal transducer activity • GTPase activity • G-protein beta-subunit binding Cellular component • cell membrane • extracellular exosome • membrane • actin filament • heterotrimeric G-protein complex • G-protein beta/gamma-subunit complex Biological process • cerebral cortex development • G-protein coupled receptor signaling pathway • cellular response to glucagon stimulus • response to lipopolysaccharide • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55970	14701
Ensembl	ENSG00000172380	ENSMUSG00000036402
UniProt	Q9UBI6	Q9DAS9
RefSeq (mRNA)	NM_018841	NM_001177556 NM_001177557 NM_001177558 NM_001177559 NM_001177560 NM_025278
RefSeq (protein)	NP_061329	NP_001171027 NP_001171028 NP_001171029 NP_001171030 NP_001171031 NP_079554
Location (UCSC)	Chr 1: 67.7 – 67.83 Mb	Chr 6: 66.9 – 67.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000172380 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036402 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, Simon MI, Shizuya H (Sep 2000). "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes". DNA Res. 7 (2): 111–20. doi:10.1093/dnares/7.2.111. PMID 10819326.
6. "Entrez Gene: GNG12 guanine nucleotide binding protein (G protein), gamma 12".

Further reading

• Morishita R, Nakayama H, Isobe T, et al. (1996). "Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C." J. Biol. Chem. 270 (49): 29469–75. doi:10.1074/jbc.270.49.29469. PMID 7493986.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Morishita R, Saga S, Kawamura N, et al. (1997). "Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain". J. Neurochem. 68 (2): 820–7. doi:10.1046/j.1471-4159.1997.68020820.x. PMID 9003074.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Asano T, Morishita R, Ueda H, Kato K (1999). "Selective association of G protein beta(4) with gamma(5) and gamma(12) subunits in bovine tissues". J. Biol. Chem. 274 (30): 21425–9. doi:10.1074/jbc.274.30.21425. PMID 10409705.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Cook LA, Schey KL, Cleator JH, et al. (2002). "Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms". Protein Sci. 10 (12): 2548–55. doi:10.1110/ps.ps.26401. PMC 2374038. PMID 11714923.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Kato C, Mizutani T, Tamaki H, et al. (2004). "Characterization of heterotrimeric G protein complexes in rice plasma membrane". Plant J. 38 (2): 320–31. doi:10.1111/j.1365-313X.2004.02046.x. PMID 15078334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.