PRKG1

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.[5][6][7]

PRKG1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRKG1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, protein kinase, cGMP-dependent, type I, PKG1, protein kinase cGMP-dependent 1
External IDsOMIM: 176894 MGI: 108174 HomoloGene: 55964 GeneCards: PRKG1
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q11.23-q21.1Start50,990,888 bp[1]
End52,298,423 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5592

19091

Ensembl

ENSG00000185532

ENSMUSG00000052920

UniProt

Q13976

P0C605

RefSeq (mRNA)

NM_001098512
NM_006258
NM_001374781
NM_001374782

NM_001013833
NM_011160

RefSeq (protein)

NP_001091982
NP_006249
NP_001361710
NP_001361711

NP_001013855
NP_035290

Location (UCSC)Chr 10: 50.99 – 52.3 MbChr 19: 30.56 – 31.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

PRKG1 has been shown to interact with:

gollark: ```[13:44:18] (node:2784) UnhandledPromiseRejectionWarning: Error: Please install 'pg' module manually at new ConnectionManager (/home/osmarks/Documents/Krist/node_modules/sequelize/lib/dialects/postgres/connection-manager.js:27:13) at new PostgresDialect (/home/osmarks/Documents/Krist/node_modules/sequelize/lib/dialects/postgres/index.js:12:28) at new Sequelize (/home/osmarks/Documents/Krist/node_modules/sequelize/lib/sequelize.js:233:18) at /home/osmarks/Documents/Krist/src/database.js:54:24 at new Promise (<anonymous>) at Function.Database.init (/home/osmarks/Documents/Krist/src/database.js:36:9) at /home/osmarks/Documents/Krist/main.js:47:11 at <anonymous> at process._tickCallback (internal/process/next_tick.js:182:7)[13:44:18] (node:2784) UnhandledPromiseRejectionWarning: Unhandled promise rejection. This error originated either by throwing inside of an async function without a catch block, or by rejecting a promise which was not handled with .catch(). (rejection id: 2)[13:44:18] (node:2784) [DEP0018] DeprecationWarning: Unhandled promise rejections are deprecated. In the future, promise rejections that are not handled will terminate the Node.js process with a non-zero exit code.```
gollark: ```[13:44:18] [Error] Uncaught error: [13:44:18] TypeError [ERR_INVALID_ARG_TYPE]: The "path" argument must be of type string at assertPath (path.js:39:11) at Object.basename (path.js:1300:5) at /home/osmarks/Documents/Krist/src/errors/errors.js:46:47 at Array.forEach (<anonymous>) at Object.<anonymous> (/home/osmarks/Documents/Krist/src/errors/errors.js:44:27) at Module._compile (internal/modules/cjs/loader.js:654:30) at Object.Module._extensions..js (internal/modules/cjs/loader.js:665:10) at Module.load (internal/modules/cjs/loader.js:566:32) at tryModuleLoad (internal/modules/cjs/loader.js:506:12) at Function.Module._load (internal/modules/cjs/loader.js:498:3)```
gollark: ```// The dialect used to connect, one of: mysql, postgres, mariadb or mssql. (sqlite not supported, fuck you Taras!)```How professional.
gollark: It errored when I tried to run it without running a redis server.
gollark: Why does krist use redis and postgreSQL?

References

  1. GRCh38: Ensembl release 89: ENSG00000185532 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000052920 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Sep 1989). "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat". FEBS Letters. 255 (2): 321–9. doi:10.1016/0014-5793(89)81114-7. PMID 2792381.
  6. Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T (April 1992). "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell Genetics. 59 (4): 270–3. doi:10.1159/000133267. PMID 1544322.
  7. "Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I".
  8. Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB (Aug 2002). "cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I". The Journal of Biological Chemistry. 277 (35): 32003–14. doi:10.1074/jbc.M112332200. PMID 12082086.
  9. Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174.
  10. Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (Jun 2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". The Journal of Biological Chemistry. 276 (26): 24153–9. doi:10.1074/jbc.M101530200. PMID 11309393.
  11. Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G (Dec 2003). "Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure". Nature Medicine. 9 (12): 1506–12. doi:10.1038/nm958. PMID 14608379.
  12. Yuasa K, Michibata H, Omori K, Yanaka N (Dec 1999). "A novel interaction of cGMP-dependent protein kinase I with troponin T". The Journal of Biological Chemistry. 274 (52): 37429–34. doi:10.1074/jbc.274.52.37429. PMID 10601315.

Further reading


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